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Dextroamphetamine Side Effects

The most commonly reported side effects of dextroamphetamine include fatigue, nausea, and headache, based on 54,671 FDA adverse event reports from 2004 to 2025. 11.0% of reports found the drug to be ineffective.

Dextroamphetamine side effects

Percentages show how often each reaction appears relative to total reports for dextroamphetamine.

1
Drug Ineffective11.0%6,009
2
Fatigue7.0%3,832
3
Nausea6.2%3,406
4
Headache5.8%3,192
5
Anxiety5.4%2,967
6
Depression4.6%2,488
7
Feeling Abnormal4.3%2,374
8
Somnolence3.8%2,072
9
Pain3.7%2,031
10
Dizziness3.7%2,021
11
Insomnia3.6%1,947
12
Off Label Use3.3%1,778
13
Vomiting2.7%1,474
14
Condition Aggravated2.7%1,449
15
Malaise2.5%1,390

These are voluntary reports and do not establish that dextroamphetamine caused these reactions.

Report severity

46.2%Serious25,238 reports
13.2%Hospitalizations7,209 reports
2.2%Fatal1,192 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dextroamphetamine drug interactions

Other drugs that appear in adverse event reports alongside dextroamphetamine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate28.5%15,554
2
Amphetamine19.5%10,671
3
Lisdexamfetamine-dimesylate2.8%1,539
4
Magnesium-oxybate2.3%1,236
5
Calcium-oxybate2.3%1,235
6
Potassium-oxybate2.3%1,235
7
Dupilumab2.2%1,191
8
Methylphenidate2.0%1,074
9
Adalimumab1.9%1,014
10
Bupropion1.5%813
11
Aripiprazole1.4%789
12
Dalfampridine1.4%768
13
Dimethyl1.2%647
14
Fingolimod1.2%633
15
Oxycodone1.2%629

Taken alongside

1
Amphetamine65.4%35,757
2
Ergocalciferol14.7%8,025
3
Acetaminophen14.2%7,766
4
Gabapentin10.0%5,447
5
Bupropion9.6%5,244
6
Albuterol9.5%5,169
7
Levothyroxine-sodium9.2%5,015
8
Ibuprofen8.7%4,749
9
Clonazepam8.7%4,743
10
Omeprazole8.2%4,510
11
Alprazolam8.2%4,460
12
Fluticasone7.8%4,276
13
Duloxetine-hydrochloride7.5%4,113
14
Oxycodone6.3%3,470
15
Modafinil6.3%3,450

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dextroamphetamine side effects

63.2% of dextroamphetamine adverse event reports involve female patients and 29.0% involve male patients. The largest age group is adult at 83%. These figures reflect who reports side effects, not underlying risk.

Sex

Female63.2%
Male29.0%
Unknown7.9%

Age group

< 20.3%
2–114.8%
12–175.7%
18–6483.0%
65+6.1%

What is dextroamphetamine used for

Conditions and purposes for which patients were taking dextroamphetamine when the adverse event was reported.

Abnormal BehaviourAccidental Drug Intake By ChildAccidental Exposure To Product By ChildAcquired Immunodeficiency SyndromeAddAdhdAdhd, Predominantly Inattentive TypeAdiposis DolorosaAdrenal InsufficiencyAdverse EventAdverse ReactionAffect LabilityAffective DisorderAggressionAgitation

Showing 15 of 439 indications

Dextroamphetamine brand names and reporting trend

Dextroamphetamine is sold under brand names including Xelstrym, Dextroamp Saccharate,amp Aspartate,dextroamp Sulfate And Amp Sulfate.

Brand names

Xelstrym5,118
Dextroamp Saccharate,amp Aspartate,dextroamp Sulfate And Amp Sulfate3,514

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dextroamphetamine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.