OpenClaim

Dexrazoxane Side Effects

The most commonly reported side effects of dexrazoxane include febrile neutropenia, off label use, and neutropenia, based on 2,075 FDA adverse event reports from 2004 to 2025.

Dexrazoxane side effects

Percentages show how often each reaction appears relative to total reports for dexrazoxane.

1
Febrile Neutropenia20.4%424
2
Off Label Use14.2%294
3
Neutropenia6.2%128
4
Pyrexia6.0%125
5
Clostridium Difficile Colitis5.1%106
6
Product Use In Unapproved Indication5.0%104
7
Cellulitis4.6%95
8
Vomiting4.2%88
9
Fungal Infection4.2%88
10
Bacterial Infection4.2%88
11
Nausea4.1%85
12
Lymphoid Tissue Hypoplasia4.0%84
13
Lymphopenia4.0%83
14
Thymus Hypoplasia4.0%82
15
Disseminated Aspergillosis3.8%79

These are voluntary reports and do not establish that dexrazoxane caused these reactions.

Report severity

96.2%Serious1,996 reports
58.1%Hospitalizations1,205 reports
10.9%Fatal226 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dexrazoxane drug interactions

Other drugs that appear in adverse event reports alongside dexrazoxane. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Doxorubicin-hydrochloride45.5%945
2
Vincristine-sulfate28.3%588
3
Cyclophosphamide22.8%473
4
Cytarabine21.8%452
5
Methotrexate19.4%403
6
Dexamethasone15.6%324
7
Etoposide15.0%311
8
Pegaspargase11.8%244
9
Daunorubicin10.1%210
10
Cisplatin9.5%197
11
Ifosfamide9.1%188
12
Hydrocortisone8.5%177
13
Prednisone7.4%154
14
Mercaptopurine6.7%139
15
Filgrastim6.6%137

Taken alongside

1
Ondansetron20.0%416
2
Dexamethasone14.8%308
3
Acetaminophen13.3%276
4
Dimenhydrinate12.0%250
5
Doxorubicin-hydrochloride10.7%222
6
Diphenhydramine9.1%188
7
Lorazepam8.9%184
8
Metoclopramide-hydrochloride8.5%177
9
Lansoprazole8.0%166
10
Furosemide7.5%156
11
Cyclophosphamide7.4%154
12
Allopurinol7.1%148
13
Mesna7.1%147
14
Filgrastim7.0%145
15
Amlodipine6.6%136

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dexrazoxane side effects

40.5% of dexrazoxane adverse event reports involve female patients and 46.5% involve male patients. The largest age group is adult at 30%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.5%
Male46.5%
Unknown13.1%

Age group

< 28.2%
2–1126.7%
12–1717.0%
18–6430.4%
65+17.7%

What is dexrazoxane used for

Conditions and purposes for which patients were taking dexrazoxane when the adverse event was reported.

Acute LeukaemiaAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAdministration Site ExtravasationAdrenocortical CarcinomaAdverse EventAntacid TherapyAcute LeukaemiaAcute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAcute Promyelocytic LeukaemiaAdjuvant TherapyAdministration Site ExtravasationAdrenal Haemorrhage

Showing 15 of 181 indications

Dexrazoxane brand names and reporting trend

Dexrazoxane is sold under the brand name Totect.

Brand names

Totect146

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dexrazoxane with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.