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Dexlansoprazole Side Effects

The most commonly reported side effects of dexlansoprazole include chronic kidney disease, acute kidney injury, and renal failure, based on 42,198 FDA adverse event reports from 2004 to 2025. 5.9% of reports found the drug to be ineffective.

Dexlansoprazole side effects

Percentages show how often each reaction appears relative to total reports for dexlansoprazole.

1
Chronic Kidney Disease38.2%16,109
2
Acute Kidney Injury18.5%7,823
3
Renal Failure16.0%6,731
4
End Stage Renal Disease11.5%4,845
5
Renal Injury10.3%4,347
6
Drug Ineffective5.9%2,505
7
Fatigue5.6%2,349
8
Off Label Use5.3%2,254
9
Tubulointerstitial Nephritis5.2%2,190
10
Nausea5.1%2,133
11
Diarrhoea4.6%1,955
12
Headache4.5%1,915
13
Pain4.5%1,883
14
Death4.3%1,831
15
Dyspnoea3.7%1,579

These are voluntary reports and do not establish that dexlansoprazole caused these reactions.

Report severity

81.0%Serious34,173 reports
17.8%Hospitalizations7,517 reports
8.9%Fatal3,736 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dexlansoprazole drug interactions

Other drugs that appear in adverse event reports alongside dexlansoprazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Esomeprazole45.6%19,255
2
Omeprazole44.9%18,940
3
Pantoprazole-sodium44.3%18,677
4
Lansoprazole42.9%18,120
5
Rabeprazole-sodium12.2%5,152
6
Naproxen10.1%4,272
7
Adalimumab3.7%1,550
8
Infliximab2.3%987
9
Rituximab2.2%912
10
Sodium-oxybate2.1%890
11
Methotrexate1.9%797
12
Etanercept1.7%735
13
Vedolizumab1.5%648
14
Sodium-bicarbonate1.4%590
15
Albuterol1.3%563

Taken alongside

1
Acetaminophen16.3%6,882
2
Ergocalciferol13.7%5,789
3
Aspirin13.0%5,472
4
Levothyroxine-sodium11.2%4,741
5
Atorvastatin-calcium10.7%4,512
6
Furosemide10.2%4,312
7
Amlodipine9.7%4,082
8
Prednisone9.6%4,049
9
Albuterol9.6%4,041
10
Ranitidine9.5%4,001
11
Lisinopril9.4%3,949
12
Gabapentin9.3%3,910
13
Metoprolol7.9%3,338
14
Fluticasone7.8%3,282
15
Famotidine7.2%3,055

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dexlansoprazole side effects

47.4% of dexlansoprazole adverse event reports involve female patients and 22.3% involve male patients. The largest age group is adult at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.4%
Male22.3%
Unknown30.3%

Age group

< 2<0.1%
2–11<0.1%
12–170.4%
18–6463.8%
65+35.6%

What is dexlansoprazole used for

Conditions and purposes for which patients were taking dexlansoprazole when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal HerniaAbdominal OperationAbdominal PainAbdominal Pain UpperAbdominal RigidityAccidental Exposure To ProductAcid Base BalanceAcid DyspepsiaAcid Peptic DiseaseAcid Reflux (esophageal)Acid Reflux (oesophageal)Acquired Oesophageal WebAdverse Event

Showing 15 of 356 indications

Dexlansoprazole brand names and reporting trend

Dexlansoprazole is sold under the brand name Dexilant.

Brand names

Dexilant4,489

Quarterly reports (20042025)

20042010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dexlansoprazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.