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Dexchlorpheniramine Side Effects

The most commonly reported side effects of dexchlorpheniramine include pyrexia, off label use, and dyspnoea, based on 10,853 FDA adverse event reports from 2004 to 2025.

Dexchlorpheniramine side effects

Percentages show how often each reaction appears relative to total reports for dexchlorpheniramine.

1
Pyrexia6.3%683
2
Off Label Use5.5%594
3
Dyspnoea5.0%548
4
Infusion Related Reaction4.9%530
5
Erythema4.8%525
6
Febrile Neutropenia4.3%468
7
Nausea3.6%396
8
Rash3.5%385
9
Neutropenia3.5%384
10
Hypersensitivity3.5%383
11
Hypotension3.5%381
12
Cytokine Release Syndrome3.5%378
13
Malaise3.3%356
14
Diarrhoea3.2%352
15
Vomiting3.1%338

These are voluntary reports and do not establish that dexchlorpheniramine caused these reactions.

Report severity

97.7%Serious10,602 reports
59.0%Hospitalizations6,407 reports
14.8%Fatal1,607 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dexchlorpheniramine drug interactions

Other drugs that appear in adverse event reports alongside dexchlorpheniramine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Paclitaxel12.5%1,353
2
Methylprednisolone12.3%1,336
3
Rituximab11.0%1,194
4
Carboplatin10.5%1,143
5
Dexamethasone7.6%829
6
Ondansetron6.2%673
7
Prednisone6.1%660
8
Ranitidine6.0%647
9
Cyclophosphamide5.9%641
10
Doxorubicin-hydrochloride5.6%607
11
Vincristine-sulfate5.2%566
12
Cetuximab5.0%546
13
Oxaliplatin4.8%521
14
Acetaminophen4.6%503
15
Aprepitant3.5%378

Taken alongside

1
Acetaminophen25.1%2,721
2
Methylprednisolone21.5%2,333
3
Dexamethasone16.0%1,734
4
Ondansetron14.3%1,556
5
Omeprazole10.1%1,092
6
Prednisone9.4%1,019
7
Furosemide9.3%1,006
8
Acyclovir9.2%998
9
Sulfamethoxazole9.2%996
10
Ranitidine8.9%961
11
Trimethoprim8.1%875
12
Hydrocortisone7.6%825
13
Pantoprazole-sodium5.5%596
14
Granisetron5.4%590
15
Famotidine5.4%584

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dexchlorpheniramine side effects

47.3% of dexchlorpheniramine adverse event reports involve female patients and 45.4% involve male patients. The largest age group is adult at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.3%
Male45.4%
Unknown7.3%

Age group

< 20.8%
2–114.4%
12–172.5%
18–6447.2%
65+45.1%

What is dexchlorpheniramine used for

Conditions and purposes for which patients were taking dexchlorpheniramine when the adverse event was reported.

AcarodermatitisAcneAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAdenocarcinoma Of ColonAdjuvant TherapyAdverse EventAllergic OedemaAllergic Transfusion ReactionAllergyAllergy ProphylaxisAnaemia Haemolytic AutoimmuneAnaesthesiaAnaphylactic Reaction

Showing 15 of 377 indications

Dexchlorpheniramine brand names and reporting trend

Dexchlorpheniramine is sold under the brand name Dexchlorpheniramine Maleate.

Brand names

Dexchlorpheniramine Maleate997

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dexchlorpheniramine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.