OpenClaim

Deutivacaftor Side Effects

The most commonly reported side effects of deutivacaftor include rash, liver function test increased, and anxiety, based on 341 FDA adverse event reports from 2009 to 2025.

Deutivacaftor side effects

Percentages show how often each reaction appears relative to total reports for deutivacaftor.

1
Rash8.5%29
2
Liver Function Test Increased7.0%24
3
Anxiety6.5%22
4
Diarrhoea6.2%21
5
Headache5.9%20
6
Fatigue5.0%17
7
Hospitalisation4.1%14
8
Infective Pulmonary Exacerbation Of Cystic Fibrosis3.8%13
9
Nausea3.5%12
10
Abdominal Pain Upper2.9%10
11
Gastrointestinal Disorder2.6%9
12
Abdominal Distension2.6%9
13
Insomnia2.6%9
14
Depression2.6%9
15
Alanine Aminotransferase Increased2.6%9

These are voluntary reports and do not establish that deutivacaftor caused these reactions.

Report severity

33.4%Serious114 reports
17.0%Hospitalizations58 reports
0.6%Fatal2 reports

Seriousness is determined by the reporter, not by OpenClaim.

Deutivacaftor drug interactions

Other drugs that appear in adverse event reports alongside deutivacaftor. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tezacaftor91.8%313
2
Vanzacaftor-calcium91.8%313
3
Aztreonam7.0%24
4
Elexacaftor-ivacaftor-tezacaftor2.9%10
5
Ivacaftor2.9%10
6
Dupilumab2.6%9
7
Dornase-alfa1.5%5
8
Abatacept0.9%3
9
Albuterol0.9%3
10
Benralizumab0.9%3
11
Insulin0.6%2
12
Lipase0.6%2
13
Pancrelipase-amylase0.6%2
14
Protease0.6%2
15
Pregabalin0.6%2

Taken alongside

1
Lipase10.0%34
2
Pancrelipase-amylase9.4%32
3
Protease9.4%32
4
Dornase-alfa8.5%29
5
Albuterol8.5%29
6
Tezacaftor7.6%26
7
Vanzacaftor-calcium7.6%26
8
Tobramycin5.0%17
9
Sodium-chloride5.0%17
10
Azithromycin3.8%13
11
Ergocalciferol3.5%12
12
Fluticasone3.2%11
13
Insulin2.6%9
14
Famotidine2.6%9
15
Formoterol2.6%9

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports deutivacaftor side effects

47.8% of deutivacaftor adverse event reports involve female patients and 23.8% involve male patients. The largest age group is adult at 70%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.8%
Male23.8%
Unknown28.4%

Age group

< 20.0%
2–118.6%
12–1717.2%
18–6470.2%
65+4.0%

What is deutivacaftor used for

Conditions and purposes for which patients were taking deutivacaftor when the adverse event was reported.

Cystic FibrosisCystic Fibrosis LungProduct Used For Unknown IndicationSkin Cosmetic Procedure

Deutivacaftor brand names and reporting trend

Deutivacaftor is sold under the brand name Alyftrek.

Brand names

Alyftrek2

Quarterly reports (20092025)

20092025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking deutivacaftor with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.