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Deutetrabenazine Side Effects

The most commonly reported side effects of deutetrabenazine include depression, dyskinesia, and death, based on 6,454 FDA adverse event reports from 2014 to 2025. 14.3% of reports found the drug to be ineffective.

Deutetrabenazine side effects

Percentages show how often each reaction appears relative to total reports for deutetrabenazine.

1
Drug Ineffective14.3%925
2
Depression7.2%463
3
Dyskinesia6.3%404
4
Death6.2%402
5
Tremor5.1%330
6
Product Use Issue5.0%321
7
Somnolence4.7%305
8
Fatigue4.5%290
9
Suicidal Ideation4.4%287
10
Insomnia4.4%282
11
Off Label Use4.1%267
12
Fall4.1%262
13
Product Use In Unapproved Indication3.7%239
14
Tardive Dyskinesia3.4%221
15
Dizziness3.3%210

These are voluntary reports and do not establish that deutetrabenazine caused these reactions.

Report severity

44.4%Serious2,865 reports
12.5%Hospitalizations806 reports
7.2%Fatal464 reports

Seriousness is determined by the reporter, not by OpenClaim.

Deutetrabenazine drug interactions

Other drugs that appear in adverse event reports alongside deutetrabenazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Valbenazine1.8%115
2
Dupilumab0.5%35
3
Sertraline-hydrochloride0.4%23
4
Aripiprazole0.4%23
5
Lamotrigine0.4%23
6
Baclofen0.3%20
7
Tetrabenazine0.3%20
8
Risperidone0.3%20
9
Doxepin-hydrochloride0.3%19
10
Quetiapine-fumarate0.3%18
11
Cariprazine-hydrochloride0.3%18
12
Sodium-oxybate0.3%18
13
Clonazepam0.3%17
14
Topiramate0.3%17
15
Acetaminophen0.3%17

Taken alongside

1
Gabapentin4.6%298
2
Atorvastatin-calcium4.5%293
3
Ergocalciferol4.1%267
4
Clonazepam3.6%233
5
Trazodone-hydrochloride3.5%225
6
Levothyroxine-sodium3.5%223
7
Lamotrigine3.3%216
8
Omeprazole3.0%192
9
Aspirin2.9%186
10
Acetaminophen2.7%177
11
Amlodipine2.7%177
12
Quetiapine-fumarate2.6%171
13
Metformin2.6%169
14
Duloxetine-hydrochloride2.6%168
15
Albuterol2.6%165

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports deutetrabenazine side effects

60.2% of deutetrabenazine adverse event reports involve female patients and 28.7% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.2%
Male28.7%
Unknown11.1%

Age group

< 20.0%
2–110.2%
12–170.5%
18–6453.0%
65+46.4%

What is deutetrabenazine used for

Conditions and purposes for which patients were taking deutetrabenazine when the adverse event was reported.

Adrenocortical Insufficiency AcuteAkathisiaAndrogen Replacement TherapyAnxietyAutism Spectrum DisorderAdverse Drug ReactionAkathisiaAlcohol AbuseAnxiety DisorderArthropathyAsthmaAttention Deficit Hyperactivity DisorderBasal Ganglion DegenerationBehaviour DisorderBipolar Disorder

Showing 15 of 138 indications

Deutetrabenazine brand names and reporting trend

Deutetrabenazine is sold under the brand name Austedo Xr.

Brand names

Austedo Xr140

Quarterly reports (20142025)

2014202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking deutetrabenazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.