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Desvenlafaxine Side Effects

The most commonly reported side effects of desvenlafaxine include nausea, anxiety, and headache, based on 31,545 FDA adverse event reports from 2005 to 2025. 8.5% of reports found the drug to be ineffective.

Desvenlafaxine side effects

Percentages show how often each reaction appears relative to total reports for desvenlafaxine.

1
Drug Ineffective8.5%2,685
2
Nausea5.0%1,576
3
Anxiety4.4%1,395
4
Headache4.3%1,360
5
Dizziness4.1%1,306
6
Fatigue4.0%1,268
7
Depression4.0%1,267
8
Nausea3.9%1,216
9
Feeling Abnormal3.8%1,200
10
Off Label Use3.6%1,134
11
Malaise3.3%1,039
12
Insomnia3.0%954
13
Pain2.9%907
14
Headache2.9%906
15
Dizziness2.8%893

These are voluntary reports and do not establish that desvenlafaxine caused these reactions.

Report severity

42.5%Serious13,410 reports
13.4%Hospitalizations4,230 reports
3.0%Fatal933 reports

Seriousness is determined by the reporter, not by OpenClaim.

Desvenlafaxine drug interactions

Other drugs that appear in adverse event reports alongside desvenlafaxine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate4.2%1,315
2
Quetiapine-fumarate2.0%627
3
Venlafaxine1.9%602
4
Bupropion1.8%581
5
Aripiprazole1.8%575
6
Pregabalin1.6%499
7
Adalimumab1.5%473
8
Sertraline-hydrochloride1.3%421
9
Alprazolam1.0%330
10
Dupilumab1.0%330
11
Duloxetine-hydrochloride1.0%329
12
Acetaminophen1.0%310
13
Fluoxetine-hydrochloride0.9%296
14
Escitalopram-oxalate0.9%281
15
Clonazepam0.9%275

Taken alongside

1
Levothyroxine-sodium8.7%2,729
2
Acetaminophen7.5%2,376
3
Ergocalciferol7.4%2,326
4
Clonazepam6.9%2,177
5
Alprazolam6.2%1,964
6
Gabapentin5.7%1,797
7
Omeprazole5.6%1,755
8
Bupropion5.5%1,728
9
Aspirin5.1%1,598
10
Trazodone-hydrochloride4.7%1,481
11
Atorvastatin-calcium4.5%1,421
12
Albuterol4.2%1,323
13
Lorazepam4.1%1,301
14
Fluticasone3.9%1,240
15
Metformin3.9%1,218

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports desvenlafaxine side effects

69.5% of desvenlafaxine adverse event reports involve female patients and 20.4% involve male patients. The largest age group is adult at 77%. These figures reflect who reports side effects, not underlying risk.

Sex

Female69.5%
Male20.4%
Unknown10.1%

Age group

< 20.3%
2–110.2%
12–171.5%
18–6477.4%
65+20.6%

What is desvenlafaxine used for

Conditions and purposes for which patients were taking desvenlafaxine when the adverse event was reported.

Abdominal PainAbnormal DreamsAccidental ExposureAcheAdjustment DisorderAdjustment Disorder With AnxietyAdjustment Disorder With Depressed MoodAdjustment Disorder With Mixed Anxiety And Depressed MoodAdjuvant TherapyAffect LabilityAffective DisorderAggressionAgitated DepressionAgitationAgoraphobia

Showing 15 of 475 indications

Desvenlafaxine brand names and reporting trend

Desvenlafaxine is sold under brand names including Desvenlafaxine, Desvenlafaxine Succinate.

Brand names

Desvenlafaxine4,102
Desvenlafaxine Succinate3,058

Quarterly reports (20052025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking desvenlafaxine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.