OpenClaim

Desmopressin Side Effects

The most commonly reported side effects of desmopressin include hyponatraemia, off label use, and headache, based on 10,045 FDA adverse event reports from 2004 to 2025. 7.0% of reports found the drug to be ineffective.

Desmopressin side effects

Percentages show how often each reaction appears relative to total reports for desmopressin.

1
Hyponatraemia8.7%875
2
Drug Ineffective7.0%704
3
Off Label Use5.1%516
4
Headache4.6%460
5
Fatigue3.3%335
6
Nausea3.1%312
7
Vomiting2.9%292
8
Dizziness2.6%257
9
Product Use In Unapproved Indication2.4%246
10
Diarrhoea2.3%229
11
Malaise2.2%221
12
Seizure2.2%221
13
Hyponatraemia2.2%220
14
Fall2.2%217
15
Drug Interaction2.1%207

These are voluntary reports and do not establish that desmopressin caused these reactions.

Report severity

72.0%Serious7,236 reports
40.1%Hospitalizations4,027 reports
7.0%Fatal708 reports

Seriousness is determined by the reporter, not by OpenClaim.

Desmopressin drug interactions

Other drugs that appear in adverse event reports alongside desmopressin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Somatropin12.0%1,210
2
Hydrocortisone3.1%311
3
Clozapine2.1%215
4
Sodium-oxybate1.8%183
5
Levothyroxine-sodium1.8%182
6
Levetiracetam1.5%152
7
Acetaminophen1.1%110
8
Risperidone1.1%107
9
Omeprazole1.0%104
10
Tranexamic-acid1.0%103
11
Ibuprofen1.0%103
12
Prednisone1.0%96
13
Rituximab1.0%96
14
Gabapentin0.9%95
15
Lamotrigine0.9%91

Taken alongside

1
Levothyroxine-sodium22.5%2,264
2
Hydrocortisone16.3%1,635
3
Acetaminophen8.0%801
4
Ergocalciferol6.8%683
5
Aspirin6.0%599
6
Omeprazole5.8%586
7
Atorvastatin-calcium4.9%495
8
Albuterol4.8%485
9
Prednisone4.4%445
10
Gabapentin4.4%440
11
Testosterone4.2%420
12
Metformin4.1%416
13
Amlodipine4.1%407
14
Pantoprazole-sodium3.6%360
15
Fluticasone3.4%342

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports desmopressin side effects

44.6% of desmopressin adverse event reports involve female patients and 42.0% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female44.6%
Male42.0%
Unknown13.4%

Age group

< 21.9%
2–1110.9%
12–179.4%
18–6451.6%
65+26.2%

What is desmopressin used for

Conditions and purposes for which patients were taking desmopressin when the adverse event was reported.

AccidentAcquired HaemophiliaAcquired Von Willebrand^s DiseaseAcromegalyActh Stimulation TestActh-producing Pituitary TumourAdh DecreasedAdh DisorderAdrenal DisorderAdrenal InsufficiencyAdrenocorticotropic Hormone DeficiencyAdverse Drug ReactionAnalgesiaAnalgesic TherapyAnti Factor Viii Antibody Increased

Showing 15 of 406 indications

Desmopressin brand names and reporting trend

Desmopressin is sold under the brand name Nocdurna.

Brand names

Nocdurna7,202

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking desmopressin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.