OpenClaim

Desloratadine Side Effects

The most commonly reported side effects of desloratadine include fatigue, nausea, and dyspnoea, based on 11,672 FDA adverse event reports from 2004 to 2025. 4.2% of reports found the drug to be ineffective.

Desloratadine side effects

Percentages show how often each reaction appears relative to total reports for desloratadine.

1
Fatigue4.3%503
2
Drug Ineffective4.2%489
3
Nausea3.5%408
4
Dyspnoea3.4%402
5
Headache3.3%387
6
Diarrhoea3.1%367
7
Pruritus3.1%358
8
Off Label Use2.9%333
9
Acute Kidney Injury2.8%326
10
Dizziness2.8%323
11
Rash2.7%314
12
Vomiting2.5%295
13
Urticaria2.2%262
14
Pain2.2%261
15
Nausea2.2%252

These are voluntary reports and do not establish that desloratadine caused these reactions.

Report severity

77.4%Serious9,035 reports
37.6%Hospitalizations4,384 reports
5.1%Fatal600 reports

Seriousness is determined by the reporter, not by OpenClaim.

Desloratadine drug interactions

Other drugs that appear in adverse event reports alongside desloratadine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole3.5%411
2
Acetaminophen3.5%405
3
Montelukast-sodium3.3%385
4
Omalizumab3.2%378
5
Adalimumab2.6%303
6
Ibuprofen2.6%299
7
Pantoprazole-sodium2.3%271
8
Fluticasone2.3%268
9
Esomeprazole2.1%247
10
Metformin1.9%222
11
Prednisone1.8%213
12
Lenalidomide1.7%195
13
Sodium-oxybate1.6%188
14
Cetirizine-hydrochloride1.6%186
15
Lansoprazole1.5%171

Taken alongside

1
Acetaminophen14.4%1,679
2
Albuterol12.5%1,464
3
Fluticasone11.5%1,342
4
Montelukast-sodium11.2%1,310
5
Levothyroxine-sodium10.9%1,273
6
Aspirin10.0%1,165
7
Omeprazole9.9%1,158
8
Furosemide8.0%931
9
Ergocalciferol8.0%929
10
Atorvastatin-calcium7.4%861
11
Pantoprazole-sodium6.7%783
12
Prednisone6.7%780
13
Amlodipine6.4%742
14
Mometasone-furoate6.3%734
15
Hydrochlorothiazide6.2%725

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports desloratadine side effects

60.6% of desloratadine adverse event reports involve female patients and 33.0% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.6%
Male33.0%
Unknown6.4%

Age group

< 20.8%
2–114.0%
12–173.9%
18–6456.9%
65+34.4%

What is desloratadine used for

Conditions and purposes for which patients were taking desloratadine when the adverse event was reported.

Abdominal PainAbnormal Sensation In EyeAccidental Exposure To Product By ChildAchromotrichia AcquiredAcneAdenoidal DisorderAdverse Drug ReactionAdverse EventAllergic CoughAllergic PharyngitisAllergic Respiratory DiseaseAllergic SinusitisAllergy ProphylaxisAllergy To AnimalAllergy To Arthropod Sting

Showing 15 of 371 indications

Desloratadine brand names and reporting trend

Desloratadine is sold under the brand name Desloratadine And Pseudoephedrine Sulfate 24 Hour.

Brand names

Desloratadine And Pseudoephedrine Sulfate 24 Hour8,314

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking desloratadine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.