The most commonly reported side effects of denosumab include off label use, death, and arthralgia, based on 196,839 FDA adverse event reports from 2007 to 2025.
Percentages show how often each reaction appears relative to total reports for denosumab.
These are voluntary reports and do not establish that denosumab caused these reactions.
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Other drugs that appear in adverse event reports alongside denosumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.
Also suspected
Taken alongside
Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.
74.4% of denosumab adverse event reports involve female patients and 14.3% involve male patients. The largest age group is elderly at 72%. These figures reflect who reports side effects, not underlying risk.
Sex
Age group
Conditions and purposes for which patients were taking denosumab when the adverse event was reported.
Showing 15 of 1,513 indications
Denosumab is sold under the brand name Xgeva.
An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.
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