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Denileukin Side Effects

The most commonly reported side effects of denileukin include capillary leak syndrome, pyrexia, and hypotension, based on 240 FDA adverse event reports from 2004 to 2025.

Denileukin side effects

Percentages show how often each reaction appears relative to total reports for denileukin.

1
Capillary Leak Syndrome10.8%26
2
Pyrexia6.3%15
3
Hypotension5.4%13
4
Vomiting5.0%12
5
Pain5.0%12
6
Blood Albumin Decreased4.6%11
7
Dyspnoea4.2%10
8
Nausea4.2%10
9
Thrombocytopenia4.2%10
10
Weight Increased3.8%9
11
Capillary Leak Syndrome3.8%9
12
Death3.8%9
13
Asthenia3.3%8
14
Oedema3.3%8
15
Febrile Neutropenia3.3%8

These are voluntary reports and do not establish that denileukin caused these reactions.

Report severity

96.7%Serious232 reports
48.3%Hospitalizations116 reports
26.3%Fatal63 reports

Seriousness is determined by the reporter, not by OpenClaim.

Denileukin drug interactions

Other drugs that appear in adverse event reports alongside denileukin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cyclophosphamide15.8%38
2
Doxorubicin-hydrochloride15.4%37
3
Vincristine-sulfate14.6%35
4
Prednisone13.3%32
5
Bexarotene11.3%27
6
Rituximab7.9%19
7
Methotrexate4.6%11
8
Vorinostat3.8%9
9
Gemcitabine3.8%9
10
Etoposide2.5%6
11
Romidepsin2.5%6
12
Pralatrexate2.5%6
13
Prednisolone1.7%4
14
Ibrutinib1.3%3
15
Bortezomib1.3%3

Taken alongside

1
Acetaminophen22.9%55
2
Dexamethasone19.2%46
3
Diphenhydramine18.8%45
4
Prednisone10.0%24
5
Cyclophosphamide8.3%20
6
Vincristine-sulfate8.3%20
7
Pegfilgrastim7.5%18
8
Doxorubicin-hydrochloride6.3%15
9
Prochlorperazine5.8%14
10
Ondansetron5.8%14
11
Pantoprazole-sodium5.8%14
12
Acyclovir5.4%13
13
Furosemide5.4%13
14
Omeprazole5.0%12
15
Lorazepam5.0%12

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports denileukin side effects

40.4% of denileukin adverse event reports involve female patients and 42.9% involve male patients. The largest age group is adult at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.4%
Male42.9%
Unknown16.7%

Age group

< 20.0%
2–110.0%
12–171.6%
18–6465.1%
65+33.3%

What is denileukin used for

Conditions and purposes for which patients were taking denileukin when the adverse event was reported.

Adult T-cell Lymphoma/leukaemiaAnaplastic Large Cell Lymphoma T- And Null-cell TypesAnaplastic Large-cell LymphomaAngioimmunoblastic T-cell LymphomaAngioimmunoblastic T-cell LymphomaB-cell LymphomaB-cell Small Lymphocytic LymphomaChronic LeukaemiaChronic Lymphocytic LeukaemiaCutaneous T-cell Lymphoma Stage IvCutaneous T-cell LymphomaCutaneous T-cell Lymphoma RecurrentCutaneous T-cell Lymphoma Stage IiDermatomyositisExtranodal Nk/t-cell Lymphoma, Nasal Type

Showing 15 of 50 indications

Denileukin brand names and reporting trend

Denileukin is sold under brand names including Ontak, Lymphir.

Brand names

Ontak42
Lymphir1

Quarterly reports (20042025)

2005201020152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking denileukin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.