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Demeclocycline Side Effects

The most commonly reported side effects of demeclocycline include hyponatraemia, hyponatraemia, and asthenia, based on 352 FDA adverse event reports from 2004 to 2025.

Demeclocycline side effects

Percentages show how often each reaction appears relative to total reports for demeclocycline.

1
Hyponatraemia9.9%35
2
Hyponatraemia7.1%25
3
Asthenia6.3%22
4
Diarrhoea6.3%22
5
Fatigue5.1%18
6
Nausea4.5%16
7
Oedema Peripheral4.5%16
8
Pneumonia4.5%16
9
Dizziness4.3%15
10
Malaise4.3%15
11
Death4.0%14
12
Drug Hypersensitivity3.7%13
13
Dehydration3.7%13
14
Acute Kidney Injury3.7%13
15
Constipation3.4%12

These are voluntary reports and do not establish that demeclocycline caused these reactions.

Report severity

78.1%Serious275 reports
56.3%Hospitalizations198 reports
17.6%Fatal62 reports

Seriousness is determined by the reporter, not by OpenClaim.

Demeclocycline drug interactions

Other drugs that appear in adverse event reports alongside demeclocycline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Carboplatin8.2%29
2
Tolvaptan6.3%22
3
Etoposide3.7%13
4
Gemcitabine3.4%12
5
Amlodipine3.1%11
6
Vasopressin3.1%11
7
Cisplatin2.8%10
8
Paclitaxel2.8%10
9
Ruxolitinib2.8%10
10
Sodium-chloride2.6%9
11
Bevacizumab2.6%9
12
Pemetrexed2.3%8
13
Mirtazapine2.3%8
14
Erlotinib-hydrochloride2.3%8
15
Doxycycline2.3%8

Taken alongside

1
Acetaminophen20.5%72
2
Aspirin17.9%63
3
Albuterol16.5%58
4
Levothyroxine-sodium15.3%54
5
Omeprazole14.8%52
6
Amlodipine13.4%47
7
Furosemide12.8%45
8
Sodium-chloride12.5%44
9
Metoprolol11.4%40
10
Ondansetron11.1%39
11
Folic-acid10.8%38
12
Prednisone10.5%37
13
Dexamethasone10.2%36
14
Oxycodone9.7%34
15
Hydrocodone9.4%33

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports demeclocycline side effects

48.3% of demeclocycline adverse event reports involve female patients and 42.3% involve male patients. The largest age group is elderly at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.3%
Male42.3%
Unknown9.4%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6444.0%
65+56.0%

What is demeclocycline used for

Conditions and purposes for which patients were taking demeclocycline when the adverse event was reported.

Adh InappropriateAntibiotic TherapyBlood SodiumBlood Sodium AbnormalBlood Sodium DecreasedBronchitisCondition AggravatedDrug Use For Unknown IndicationFluid RetentionGraft Versus Host DiseaseHyponatraemiaHypotensionHyponatraemiaHypotensionIll-defined Disorder

Showing 15 of 26 indications

Demeclocycline brand names and reporting trend

Demeclocycline is sold under the brand name Demeclocycline Hydrochloride.

Brand names

Demeclocycline Hydrochloride5

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking demeclocycline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.