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Degarelix Side Effects

The most commonly reported side effects of degarelix include fatigue, injection site pain, and hot flush, based on 5,711 FDA adverse event reports from 2004 to 2025.

Degarelix side effects

Percentages show how often each reaction appears relative to total reports for degarelix.

1
Fatigue6.6%378
2
Injection Site Pain5.4%308
3
Hot Flush5.3%303
4
Injection Site Erythema4.3%248
5
Asthenia3.7%212
6
Death3.4%196
7
Injection Site Swelling3.3%188
8
Pyrexia3.1%179
9
Product Storage Error3.1%177
10
Fall3.1%176
11
Prostatic Specific Antigen Increased2.8%160
12
Nausea2.7%152
13
Off Label Use2.7%152
14
Dizziness2.6%149
15
Pain2.5%144

These are voluntary reports and do not establish that degarelix caused these reactions.

Report severity

67.2%Serious3,835 reports
35.1%Hospitalizations2,003 reports
11.5%Fatal659 reports

Seriousness is determined by the reporter, not by OpenClaim.

Degarelix drug interactions

Other drugs that appear in adverse event reports alongside degarelix. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Enzalutamide10.0%571
2
Abiraterone-acetate9.5%540
3
Leuprolide5.7%326
4
Denosumab4.8%274
5
Apalutamide4.6%260
6
Docetaxel4.0%229
7
Prednisone3.5%201
8
Bicalutamide2.2%126
9
Darolutamide1.8%105
10
Relugolix1.4%81
11
Zoledronic-acid1.2%68
12
Dexamethasone1.1%60
13
Cabazitaxel1.0%59
14
Prednisolone1.0%58
15
Aspirin0.9%49

Taken alongside

1
Aspirin8.8%502
2
Prednisone6.2%356
3
Ergocalciferol6.2%355
4
Acetaminophen6.1%348
5
Atorvastatin-calcium5.9%337
6
Denosumab5.8%332
7
Tamsulosin-hydrochloride5.7%327
8
Amlodipine5.3%304
9
Calcium4.8%276
10
Bicalutamide4.5%258
11
Metformin4.5%255
12
Metoprolol4.0%229
13
Furosemide3.9%220
14
Lisinopril3.3%186
15
Simvastatin3.2%185

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports degarelix side effects

2.5% of degarelix adverse event reports involve female patients and 72.8% involve male patients. The largest age group is elderly at 81%. These figures reflect who reports side effects, not underlying risk.

Sex

Female2.5%
Male72.8%
Unknown24.8%

Age group

< 2<0.1%
2–110.0%
12–170.0%
18–6418.5%
65+81.5%

What is degarelix used for

Conditions and purposes for which patients were taking degarelix when the adverse event was reported.

Accidental ExposureAdenocarcinomaAdrenal SuppressionAndrogen TherapyAntiandrogen TherapyAdenocarcinoma GastricAdenocarcinoma PancreasAnal FistulaAndrogen TherapyAntacid TherapyAntiandrogen TherapyAsthmaBenign Prostatic HyperplasiaBile Duct CancerBladder Cancer

Showing 15 of 120 indications

Degarelix brand names and reporting trend

Degarelix is sold under the brand name Degarelix Acetate.

Brand names

Degarelix Acetate2,740

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking degarelix with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.