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Darunavir Side Effects

The most commonly reported side effects of darunavir include toxicity to various agents, completed suicide, and completed suicide, based on 29,052 FDA adverse event reports from 2004 to 2025.

Darunavir side effects

Percentages show how often each reaction appears relative to total reports for darunavir.

1
Toxicity To Various Agents5.9%1,725
2
Completed Suicide5.9%1,709
3
Completed Suicide5.1%1,474
4
Drug Abuse5.0%1,459
5
Death5.0%1,458
6
Bone Density Decreased4.8%1,409
7
Pain4.8%1,383
8
Anxiety4.4%1,277
9
Emotional Distress4.4%1,275
10
Foetal Exposure During Pregnancy4.3%1,236
11
Chronic Kidney Disease4.2%1,219
12
Anhedonia3.9%1,126
13
Drug Interaction3.8%1,092
14
Renal Failure3.5%1,025
15
Osteoporosis3.2%936

These are voluntary reports and do not establish that darunavir caused these reactions.

Report severity

88.9%Serious25,829 reports
23.1%Hospitalizations6,698 reports
33.1%Fatal9,610 reports

Seriousness is determined by the reporter, not by OpenClaim.

Darunavir drug interactions

Other drugs that appear in adverse event reports alongside darunavir. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ritonavir28.8%8,362
2
Tenofovir28.6%8,307
3
Emtricitabine25.2%7,328
4
Raltegravir-potassium10.9%3,171
5
Cobicistat9.3%2,691
6
Lamivudine9.1%2,637
7
Acetaminophen7.6%2,208
8
Dolutegravir6.7%1,957
9
Abacavir5.8%1,692
10
Etravirine5.5%1,612
11
Efavirenz5.2%1,517
12
Zidovudine5.2%1,508
13
Alprazolam4.4%1,286
14
Oxycodone3.7%1,084
15
Diphenhydramine3.6%1,052

Taken alongside

1
Tenofovir14.7%4,284
2
Ritonavir14.7%4,273
3
Emtricitabine14.2%4,120
4
Cobicistat9.0%2,603
5
Raltegravir-potassium6.1%1,772
6
Lamivudine5.4%1,576
7
Dolutegravir4.7%1,374
8
Abacavir3.6%1,043
9
Sulfamethoxazole3.2%931
10
Acetaminophen2.9%835
11
Trimethoprim2.8%816
12
Etravirine2.7%788
13
Aspirin2.7%779
14
Zidovudine2.5%734
15
Atorvastatin-calcium2.4%688

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports darunavir side effects

32.1% of darunavir adverse event reports involve female patients and 52.5% involve male patients. The largest age group is adult at 89%. These figures reflect who reports side effects, not underlying risk.

Sex

Female32.1%
Male52.5%
Unknown15.4%

Age group

< 23.1%
2–110.3%
12–171.0%
18–6488.6%
65+6.9%

What is darunavir used for

Conditions and purposes for which patients were taking darunavir when the adverse event was reported.

Abdominal PainAccidental OverdoseAcquired Immunodeficiency SyndromeAcute Coronary SyndromeAcute Hiv InfectionAdverse Drug ReactionAdverse ReactionAlcohol AbuseAlcohol PoisoningAlcohol UseAlcoholicAlcoholismAnti-infective TherapyAntifungal ProphylaxisAntiretroviral Therapy

Showing 15 of 215 indications

Darunavir brand names and reporting trend

Darunavir is sold under brand names including Prezcobix, Symtuza, Darunavir And Ritonavir.

Brand names

Prezcobix9,679
Symtuza7,584
Darunavir And Ritonavir9

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking darunavir with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.