OpenClaim

Daridorexant Side Effects

The most commonly reported side effects of daridorexant include insomnia, nightmare, and somnolence, based on 2,278 FDA adverse event reports from 2005 to 2025. 19.8% of reports found the drug to be ineffective.

Daridorexant side effects

Percentages show how often each reaction appears relative to total reports for daridorexant.

1
Drug Ineffective19.8%451
2
Insomnia12.4%282
3
Nightmare11.9%270
4
Somnolence7.0%160
5
Fatigue6.6%151
6
Headache6.5%149
7
Product Availability Issue6.5%147
8
Abnormal Dreams5.5%126
9
Inappropriate Schedule Of Product Administration5.3%120
10
Feeling Abnormal5.2%118
11
Wrong Technique In Product Usage Process3.7%85
12
Nausea3.2%74
13
Dizziness3.2%73
14
Therapeutic Product Effect Incomplete3.2%73
15
Hallucination3.0%69

These are voluntary reports and do not establish that daridorexant caused these reactions.

Report severity

24.5%Serious558 reports
7.0%Hospitalizations159 reports
2.3%Fatal52 reports

Seriousness is determined by the reporter, not by OpenClaim.

Daridorexant drug interactions

Other drugs that appear in adverse event reports alongside daridorexant. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Diazepam0.7%16
2
Oxycodone0.6%14
3
Ibuprofen0.6%13
4
Acetaminophen0.5%12
5
Venlafaxine0.5%12
6
Tramadol-hydrochloride0.5%11
7
Pregabalin0.5%11
8
Alprazolam0.4%10
9
Propranolol-hydrochloride0.4%10
10
Esketamine-hydrochloride0.4%9
11
Aripiprazole0.4%9
12
Cetirizine-hydrochloride0.4%8
13
Isoniazid0.4%8
14
Lithium0.4%8
15
Lumateperone0.3%7

Taken alongside

1
Levothyroxine-sodium2.7%62
2
Gabapentin2.4%54
3
Ergocalciferol2.3%53
4
Alprazolam2.2%49
5
Atorvastatin-calcium2.1%47
6
Sertraline-hydrochloride1.8%41
7
Acetaminophen1.8%40
8
Omeprazole1.8%40
9
Trazodone-hydrochloride1.7%39
10
Bupropion1.7%38
11
Zolpidem-tartrate1.5%35
12
Quetiapine-fumarate1.5%35
13
Lorazepam1.5%35
14
Metformin1.5%35
15
Clonazepam1.5%34

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports daridorexant side effects

60.3% of daridorexant adverse event reports involve female patients and 33.9% involve male patients. The largest age group is adult at 64%. These figures reflect who reports side effects, not underlying risk.

Sex

Female60.3%
Male33.9%
Unknown5.8%

Age group

< 20.0%
2–110.0%
12–170.2%
18–6464.0%
65+35.8%

What is daridorexant used for

Conditions and purposes for which patients were taking daridorexant when the adverse event was reported.

AcneCircadian Rhythm Sleep DisorderDelayed Sleep PhaseDeliriumDepressionGeneralised Anxiety DisorderHypertensionIll-defined DisorderInitial InsomniaInsomniaMiddle InsomniaNightmareProduct Used For Unknown IndicationPersistent Depressive DisorderPoisoning Deliberate

Showing 15 of 26 indications

Daridorexant brand names and reporting trend

Daridorexant is sold under the brand name Quviviq.

Brand names

Quviviq63

Quarterly reports (20052025)

20052025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking daridorexant with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.