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Daprodustat Side Effects

The most commonly reported side effects of daprodustat include hospitalisation, product use issue, and off label use, based on 1,696 FDA adverse event reports from 2008 to 2025.

Daprodustat side effects

Percentages show how often each reaction appears relative to total reports for daprodustat.

1
Hospitalisation14.5%246
2
Product Use Issue7.4%126
3
Off Label Use7.4%125
4
Death6.3%106
5
Cardiac Failure5.0%84
6
Renal Impairment4.9%83
7
Haemoglobin Decreased4.8%81
8
Dysphagia3.9%66
9
Haemoglobin Increased3.7%63
10
Marasmus3.4%57
11
Nephrogenic Anaemia2.9%50
12
Cerebral Infarction2.9%50
13
Fall2.8%48
14
Condition Aggravated2.5%42
15
Pneumonia2.5%42

These are voluntary reports and do not establish that daprodustat caused these reactions.

Report severity

95.1%Serious1,613 reports
54.3%Hospitalizations921 reports
23.1%Fatal391 reports

Seriousness is determined by the reporter, not by OpenClaim.

Daprodustat drug interactions

Other drugs that appear in adverse event reports alongside daprodustat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Darbepoetin-alfa10.6%179
2
Epoetin2.6%44
3
Valsartan1.8%31
4
Sacubitril1.8%30
5
Furosemide1.3%22
6
Tolvaptan1.1%18
7
Tenapanor-hydrochloride1.1%18
8
Dapagliflozin0.9%16
9
Prednisolone0.8%13
10
Spironolactone0.7%12
11
Vadadustat0.7%12
12
Tacrolimus0.6%11
13
Bisoprolol-fumarate0.6%11
14
Sodium-zirconium-cyclosilicate0.6%11
15
Ferric-citrate0.6%11

Taken alongside

1
Febuxostat9.5%161
2
Amlodipine8.7%147
3
Furosemide8.6%146
4
Darbepoetin-alfa7.3%124
5
Ferrous-fumarate7.0%119
6
Aspirin6.4%108
7
Lansoprazole5.5%93
8
Valsartan5.5%93
9
Vonoprazan-fumarate4.9%83
10
Nifedipine4.7%79
11
Bisoprolol-fumarate4.5%77
12
Sacubitril4.4%74
13
Carvedilol4.0%68
14
Tolvaptan3.6%61
15
Magnesium-oxide3.6%61

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports daprodustat side effects

13.7% of daprodustat adverse event reports involve female patients and 16.4% involve male patients. The largest age group is elderly at 79%. These figures reflect who reports side effects, not underlying risk.

Sex

Female13.7%
Male16.4%
Unknown69.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6420.6%
65+79.4%

What is daprodustat used for

Conditions and purposes for which patients were taking daprodustat when the adverse event was reported.

AnaemiaAutoimmune Haemolytic AnaemiaCardiac Failure ChronicChronic Kidney DiseaseHaemoglobin DecreasedHypertensionMyelodysplastic SyndromeNephrogenic AnaemiaNephrogenic AnaemiaNephropathy ToxicNephrotic SyndromeProduct Used For Unknown IndicationPsoriatic ArthropathyPancytopeniaProduct Used For Unknown Indication

Showing 15 of 20 indications

Daprodustat brand names and reporting trend

Daprodustat is sold under the brand name Jesduvroq.

Brand names

Jesduvroq2,308

Quarterly reports (20082025)

200820202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking daprodustat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.