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Dalfopristin Side Effects

The most commonly reported side effects of dalfopristin include sepsis, death, and thrombocytopenia, based on 126 FDA adverse event reports from 2004 to 2025. 4.8% of reports found the drug to be ineffective.

Dalfopristin side effects

Percentages show how often each reaction appears relative to total reports for dalfopristin.

1
Sepsis7.1%9
2
Death5.6%7
3
Thrombocytopenia4.8%6
4
Blood Bilirubin Increased4.8%6
5
Death4.8%6
6
Rash4.8%6
7
Off Label Use4.8%6
8
Drug Ineffective4.8%6
9
Anaemia4.0%5
10
Drug Ineffective4.0%5
11
Blood Creatinine Increased4.0%5
12
Nausea4.0%5
13
Pyrexia4.0%5
14
Myalgia4.0%5
15
Pyrexia4.0%5

These are voluntary reports and do not establish that dalfopristin caused these reactions.

Report severity

77.8%Serious98 reports
23.0%Hospitalizations29 reports
41.3%Fatal52 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dalfopristin drug interactions

Other drugs that appear in adverse event reports alongside dalfopristin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quinupristin54.0%68
2
Daptomycin25.4%32
3
Linezolid7.9%10
4
Vancomycin5.6%7
5
Sulfamethoxazole4.8%6
6
Ceftriaxone-sodium4.8%6
7
Amphotericin-b4.0%5
8
Voriconazole4.0%5
9
Caspofungin-acetate3.2%4
10
Clofarabine2.4%3
11
Rifampin2.4%3
12
Tacrolimus2.4%3
13
Gentamicin-sulfate2.4%3
14
Ampicillin2.4%3
15
Trimethoprim2.4%3

Taken alongside

1
Quinupristin36.5%46
2
Vancomycin22.2%28
3
Linezolid15.9%20
4
Meropenem10.3%13
5
Pantoprazole-sodium8.7%11
6
Heparin7.9%10
7
Cefepime-hydrochloride7.9%10
8
Daptomycin7.9%10
9
Furosemide7.1%9
10
Insulin7.1%9
11
Acetaminophen6.3%8
12
Metoprolol6.3%8
13
Gentamicin-sulfate6.3%8
14
Aspirin5.6%7
15
Fentanyl5.6%7

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dalfopristin side effects

33.3% of dalfopristin adverse event reports involve female patients and 47.6% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.3%
Male47.6%
Unknown19.0%

Age group

< 20.0%
2–115.8%
12–174.7%
18–6460.5%
65+29.1%

What is dalfopristin used for

Conditions and purposes for which patients were taking dalfopristin when the adverse event was reported.

Abdominal Wall AbscessAbscessActinomycosisAnxietyArthritis BacterialBacterial InfectionBacteraemiaCystic FibrosisDevice Related InfectionDrug Use For Unknown IndicationEndocarditisEndocarditis EnterococcalEndocarditis StaphylococcalEnterococcal InfectionEnterococcal Infection

Showing 15 of 35 indications

Dalfopristin brand names and reporting trend

Dalfopristin is sold under the brand name Synercid.

Brand names

Synercid21

Quarterly reports (20042025)

2005201020202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dalfopristin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.