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Dacomitinib Side Effects

The most commonly reported side effects of dacomitinib include death, diarrhoea, and rash, based on 733 FDA adverse event reports from 2012 to 2025.

Dacomitinib side effects

Percentages show how often each reaction appears relative to total reports for dacomitinib.

1
Death31.9%234
2
Diarrhoea15.7%115
3
Rash15.3%112
4
Neoplasm Progression10.6%78
5
Paronychia7.8%57
6
Blood Pressure Increased6.3%46
7
Malignant Neoplasm Progression5.6%41
8
Pruritus4.8%35
9
Off Label Use4.6%34
10
Dyspnoea4.2%31
11
Decreased Appetite4.0%29
12
Vomiting3.8%28
13
Pain3.7%27
14
Drug Interaction3.5%26
15
Carcinoembryonic Antigen Increased3.5%26

These are voluntary reports and do not establish that dacomitinib caused these reactions.

Report severity

92.2%Serious676 reports
28.5%Hospitalizations209 reports
44.2%Fatal324 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dacomitinib drug interactions

Other drugs that appear in adverse event reports alongside dacomitinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Osimertinib-mesylate4.0%29
2
Erlotinib-hydrochloride2.2%16
3
Bevacizumab2.0%15
4
Carboplatin2.0%15
5
Metoprolol2.0%15
6
Pemetrexed1.6%12
7
Doxycycline1.5%11
8
Afatinib1.5%11
9
Gefitinib1.5%11
10
Loratadine1.5%11
11
Oxycodone1.2%9
12
Morphine-sulfate1.2%9
13
Prazosin-hydrochloride1.1%8
14
Duloxetine-hydrochloride1.1%8
15
Bupropion1.1%8

Taken alongside

1
Loperamide-hydrochloride4.4%32
2
Doxycycline3.5%26
3
Amlodipine3.3%24
4
Hydrocortisone2.6%19
5
Acetaminophen2.3%17
6
Folic-acid2.3%17
7
Ranitidine2.3%17
8
Dexamethasone2.2%16
9
Metformin2.0%15
10
Ondansetron1.9%14
11
Zoledronic-acid1.9%14
12
Clindamycin1.8%13
13
Levothyroxine-sodium1.6%12
14
Tramadol-hydrochloride1.6%12
15
Metoclopramide-hydrochloride1.6%12

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dacomitinib side effects

46.0% of dacomitinib adverse event reports involve female patients and 40.1% involve male patients. The largest age group is adult at 50%. These figures reflect who reports side effects, not underlying risk.

Sex

Female46.0%
Male40.1%
Unknown13.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6450.0%
65+50.0%

What is dacomitinib used for

Conditions and purposes for which patients were taking dacomitinib when the adverse event was reported.

AdenocarcinomaAdenocarcinomaAdenocarcinoma MetastaticAdenosquamous Cell Lung CancerBipolar DisorderBone CancerBronchial CarcinomaBladder CancerBronchial CarcinomaChemotherapyColorectal Cancer MetastaticCervix CarcinomaEgfr Gene MutationEgfr Gene MutationFollicle Centre Lymphoma, Follicular Grade I, Ii, Iii

Showing 15 of 55 indications

Dacomitinib brand names and reporting trend

Dacomitinib is sold under the brand name Vizimpro.

Brand names

Vizimpro707

Quarterly reports (20122025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dacomitinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.