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Dacarbazine Side Effects

The most commonly reported side effects of dacarbazine include off label use, febrile neutropenia, and neutropenia, based on 7,412 FDA adverse event reports from 2004 to 2025. 4.2% of reports found the drug to be ineffective.

Dacarbazine side effects

Percentages show how often each reaction appears relative to total reports for dacarbazine.

1
Off Label Use7.8%581
2
Febrile Neutropenia7.8%575
3
Neutropenia6.2%457
4
Drug Ineffective4.2%313
5
Pyrexia4.2%310
6
Neuropathy Peripheral3.7%275
7
Nausea3.4%251
8
Disease Progression3.3%248
9
Product Use In Unapproved Indication3.3%242
10
Anaemia3.0%225
11
Diarrhoea2.8%208
12
Vomiting2.7%202
13
Hodgkin^s Disease2.6%192
14
Thrombocytopenia2.6%190
15
Malignant Neoplasm Progression2.4%181

These are voluntary reports and do not establish that dacarbazine caused these reactions.

Report severity

95.1%Serious7,050 reports
38.6%Hospitalizations2,860 reports
17.5%Fatal1,295 reports

Seriousness is determined by the reporter, not by OpenClaim.

Dacarbazine drug interactions

Other drugs that appear in adverse event reports alongside dacarbazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Doxorubicin-hydrochloride71.5%5,299
2
Vinblastine-sulfate54.7%4,057
3
Bleomycin-sulfate37.0%2,740
4
Brentuximab-vedotin31.5%2,334
5
Etoposide18.5%1,373
6
Cyclophosphamide17.8%1,319
7
Vincristine-sulfate15.6%1,153
8
Dexamethasone10.6%782
9
Prednisone8.0%591
10
Ifosfamide7.7%569
11
Cisplatin7.6%564
12
Procarbazine-hydrochloride7.6%561
13
Gemcitabine5.5%408
14
Cytarabine5.0%370
15
Nivolumab4.8%353

Taken alongside

1
Doxorubicin-hydrochloride10.1%749
2
Vinblastine-sulfate9.8%725
3
Bleomycin-sulfate6.1%450
4
Dexamethasone4.6%339
5
Ondansetron4.0%295
6
Sulfamethoxazole2.5%188
7
Acyclovir2.4%176
8
Acetaminophen2.4%175
9
Prednisone2.2%164
10
Trimethoprim2.2%160
11
Vincristine-sulfate1.9%144
12
Filgrastim1.9%138
13
Cyclophosphamide1.8%132
14
Pantoprazole-sodium1.7%128
15
Etoposide1.7%128

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports dacarbazine side effects

35.2% of dacarbazine adverse event reports involve female patients and 42.0% involve male patients. The largest age group is adult at 69%. These figures reflect who reports side effects, not underlying risk.

Sex

Female35.2%
Male42.0%
Unknown22.8%

Age group

< 21.6%
2–113.4%
12–173.7%
18–6469.3%
65+22.0%

What is dacarbazine used for

Conditions and purposes for which patients were taking dacarbazine when the adverse event was reported.

Abdominal NeoplasmAccidental ExposureAcquired Immunodeficiency SyndromeAcral Lentiginous MelanomaAcral Lentiginous Melanoma Stage UnspecifiedAdenocarcinoma GastricAdenomatous Polyposis ColiAlveolar RhabdomyosarcomaAlveolar Soft Part SarcomaAlveolar Soft Part Sarcoma MetastaticAmeloblastomaAnaplastic Large-cell LymphomaAnaplastic Lymphoma Kinase Gene MutationAngiosarcomaAngiosarcoma Metastatic

Showing 15 of 397 indications

Dacarbazine brand names and reporting trend

Dacarbazine is sold under the brand name Dtic-dome.

Brand names

Dtic-dome8,301

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking dacarbazine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.