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Cyclothiazide Side Effects

The most commonly reported side effects of cyclothiazide include pneumonia, sepsis, and renal failure acute, based on 185 FDA adverse event reports from 2004 to 2025. 2.7% of reports found the drug to be ineffective.

Cyclothiazide side effects

Percentages show how often each reaction appears relative to total reports for cyclothiazide.

1
Pneumonia5.9%11
2
Sepsis5.4%10
3
Renal Failure Acute4.9%9
4
Hypotension4.3%8
5
Nausea3.8%7
6
Dehydration3.8%7
7
Diarrhoea3.2%6
8
Diarrhoea3.2%6
9
General Physical Health Deterioration3.2%6
10
Tumour Lysis Syndrome3.2%6
11
Plasma Cell Myeloma3.2%6
12
Pyrexia3.2%6
13
Headache3.2%6
14
Dehydration2.7%5
15
Metabolic Acidosis2.7%5

These are voluntary reports and do not establish that cyclothiazide caused these reactions.

Report severity

84.3%Serious156 reports
62.7%Hospitalizations116 reports
17.3%Fatal32 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cyclothiazide drug interactions

Other drugs that appear in adverse event reports alongside cyclothiazide. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Lenalidomide28.1%52
2
Paclitaxel6.5%12
3
Dexamethasone5.9%11
4
Carboplatin3.8%7
5
Bortezomib3.2%6
6
Azacitidine3.2%6
7
Thalidomide2.7%5
8
Gemcitabine2.7%5
9
Cyclophosphamide2.7%5
10
Abacavir2.2%4
11
Paroxetine2.2%4
12
Doxorubicin-hydrochloride2.2%4
13
Prednisone2.2%4
14
Adalimumab2.2%4
15
Ritonavir1.6%3

Taken alongside

1
Acetaminophen20.0%37
2
Dexamethasone19.5%36
3
Aspirin16.8%31
4
Ondansetron11.9%22
5
Furosemide11.9%22
6
Oxycodone10.8%20
7
Amlodipine9.7%18
8
Insulin9.2%17
9
Metoprolol8.1%15
10
Allopurinol8.1%15
11
Prednisone7.6%14
12
Lisinopril7.6%14
13
Warfarin7.6%14
14
Prochlorperazine7.0%13
15
Sodium-chloride6.5%12

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cyclothiazide side effects

49.2% of cyclothiazide adverse event reports involve female patients and 49.7% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.2%
Male49.7%
Unknown1.1%

Age group

< 22.7%
2–112.7%
12–173.4%
18–6452.7%
65+38.5%

What is cyclothiazide used for

Conditions and purposes for which patients were taking cyclothiazide when the adverse event was reported.

Acute Kidney InjuryBlood PressureChest PainChronic Kidney DiseaseDehydrationDrug Use For Unknown IndicationEncephalitisFluid ReplacementGastrointestinal DisorderHypercalcaemiaHyperchloraemiaHypertensionHypotensionHypertensionMetabolic Acidosis

Showing 15 of 27 indications

Cyclothiazide brand names and reporting trend

Cyclothiazide is sold under the brand name Anhydron.

Brand names

Anhydron3

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cyclothiazide with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.