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Cyclosporine Side Effects

The most commonly reported side effects of cyclosporine include off label use, eye irritation, and product use in unapproved indication, based on 131,683 FDA adverse event reports from 2004 to 2025. 11.5% of reports found the drug to be ineffective.

Cyclosporine side effects

Percentages show how often each reaction appears relative to total reports for cyclosporine.

1
Drug Ineffective11.5%15,107
2
Off Label Use7.9%10,405
3
Eye Irritation6.0%7,889
4
Product Use In Unapproved Indication4.4%5,786
5
Eye Pain3.0%3,918
6
Headache2.8%3,681
7
Nausea2.8%3,639
8
Fatigue2.7%3,540
9
Diarrhoea2.7%3,496
10
Condition Aggravated2.6%3,483
11
Pyrexia2.6%3,459
12
Pain2.5%3,281
13
Pneumonia2.4%3,149
14
Rash2.2%2,943
15
Pruritus2.1%2,819

These are voluntary reports and do not establish that cyclosporine caused these reactions.

Report severity

71.2%Serious93,757 reports
25.5%Hospitalizations33,531 reports
14.0%Fatal18,492 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cyclosporine drug interactions

Other drugs that appear in adverse event reports alongside cyclosporine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Mycophenolate14.8%19,435
2
Methotrexate10.8%14,168
3
Prednisone7.3%9,640
4
Prednisolone6.5%8,595
5
Tacrolimus5.9%7,762
6
Methylprednisolone5.5%7,233
7
Cyclophosphamide5.3%6,915
8
Fludarabine-phosphate5.2%6,830
9
Rituximab5.1%6,766
10
Azathioprine4.7%6,250
11
Adalimumab4.6%6,050
12
Etanercept4.3%5,723
13
Infliximab4.1%5,377
14
Busulfan3.6%4,787
15
Tocilizumab2.6%3,397

Taken alongside

1
Prednisone9.3%12,292
2
Ergocalciferol5.5%7,180
3
Mycophenolate5.4%7,161
4
Acetaminophen5.3%6,971
5
Levothyroxine-sodium5.1%6,725
6
Methotrexate4.8%6,276
7
Aspirin4.6%6,004
8
Prednisolone4.2%5,483
9
Omeprazole4.1%5,446
10
Methylprednisolone4.1%5,380
11
Furosemide3.9%5,200
12
Amlodipine3.9%5,155
13
Acyclovir3.8%4,958
14
Atorvastatin-calcium3.1%4,109
15
Folic-acid3.1%4,029

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cyclosporine side effects

52.7% of cyclosporine adverse event reports involve female patients and 34.9% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.7%
Male34.9%
Unknown12.4%

Age group

< 22.4%
2–117.8%
12–174.4%
18–6458.1%
65+27.4%

What is cyclosporine used for

Conditions and purposes for which patients were taking cyclosporine when the adverse event was reported.

5q Minus SyndromeAbdominal DiscomfortAbdominal PainAbnormal Sensation In EyeAbo IncompatibilityAccidental OverdoseAcquired Amegakaryocytic ThrombocytopeniaAcquired Antithrombin Iii DeficiencyAcquired Complement Deficiency DiseaseAcquired Epidermolysis BullosaAcquired HaemophiliaAcquired Haemophilia With Anti Fviii, Xi, Or XiiiAcrodermatitisAcute Biphenotypic LeukaemiaAcute Disseminated Encephalomyelitis

Showing 15 of 2,047 indications

Cyclosporine brand names and reporting trend

Cyclosporine is sold under the brand name Verkazia.

Brand names

Verkazia95,153

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cyclosporine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.