OpenClaim

Cyclizine Side Effects

The most commonly reported side effects of cyclizine include vomiting, nausea, and diarrhoea, based on 6,232 FDA adverse event reports from 2004 to 2025.

Cyclizine side effects

Percentages show how often each reaction appears relative to total reports for cyclizine.

1
Vomiting8.9%556
2
Nausea8.2%513
3
Diarrhoea7.8%483
4
Off Label Use4.7%296
5
Dyspnoea4.6%287
6
Fatigue4.5%280
7
Dizziness4.2%264
8
Pyrexia3.8%239
9
Abdominal Pain3.8%234
10
Constipation3.5%216
11
Acute Kidney Injury3.3%207
12
Neutropenic Sepsis3.2%200
13
Headache3.1%191
14
Malaise3.0%188
15
Febrile Neutropenia2.8%176

These are voluntary reports and do not establish that cyclizine caused these reactions.

Report severity

98.4%Serious6,130 reports
55.0%Hospitalizations3,429 reports
13.4%Fatal836 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cyclizine drug interactions

Other drugs that appear in adverse event reports alongside cyclizine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Trastuzumab6.2%384
2
Ondansetron5.6%347
3
Docetaxel5.0%311
4
Dexamethasone4.6%287
5
Omeprazole4.5%282
6
Pertuzumab4.1%258
7
Cyclophosphamide4.1%255
8
Carboplatin3.9%242
9
Capecitabine3.2%198
10
Etoposide3.1%195
11
Acetaminophen3.0%189
12
Prednisolone3.0%185
13
Paclitaxel2.9%183
14
Lansoprazole2.8%176
15
Doxorubicin-hydrochloride2.8%172

Taken alongside

1
Acetaminophen39.0%2,430
2
Omeprazole28.3%1,765
3
Ondansetron21.8%1,358
4
Lansoprazole19.5%1,218
5
Metoclopramide-hydrochloride16.6%1,033
6
Dexamethasone14.8%921
7
Morphine-sulfate14.5%904
8
Albuterol14.2%887
9
Furosemide10.7%665
10
Amoxicillin10.3%644
11
Atorvastatin-calcium10.0%623
12
Loperamide-hydrochloride9.9%620
13
Dihydrocodeine-bitartrate9.8%610
14
Folic-acid9.3%578
15
Aspirin9.0%559

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cyclizine side effects

61.8% of cyclizine adverse event reports involve female patients and 26.9% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female61.8%
Male26.9%
Unknown11.3%

Age group

< 21.7%
2–111.8%
12–173.2%
18–6456.5%
65+36.8%

What is cyclizine used for

Conditions and purposes for which patients were taking cyclizine when the adverse event was reported.

Abdominal PainAbdominal Pain UpperAcute Lymphocytic LeukaemiaAdverse EventAnaesthesiaAnalgesic TherapyAntiallergic TherapyAntiemetic Supportive CareAnxietyAbdominal PainAbdominal Pain UpperAdverse Drug ReactionAnalgesic TherapyAntiemetic Supportive CareBlood Cholesterol

Showing 15 of 116 indications

Cyclizine brand names and reporting trend

Cyclizine is sold under the brand name Marezine.

Brand names

Marezine7,200

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cyclizine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.