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Crizotinib Side Effects

The most commonly reported side effects of crizotinib include death, disease progression, and neoplasm progression, based on 12,493 FDA adverse event reports from 2011 to 2025.

Crizotinib side effects

Percentages show how often each reaction appears relative to total reports for crizotinib.

1
Death17.4%2,178
2
Disease Progression9.1%1,139
3
Neoplasm Progression8.9%1,116
4
Nausea8.3%1,041
5
Diarrhoea6.3%789
6
Vomiting5.9%734
7
Fatigue4.2%519
8
Off Label Use3.7%461
9
Oedema Peripheral3.3%413
10
Dyspnoea3.3%412
11
Constipation3.2%405
12
Lung Neoplasm Malignant3.1%383
13
Visual Impairment3.0%380
14
Decreased Appetite2.9%359
15
Asthenia2.6%325

These are voluntary reports and do not establish that crizotinib caused these reactions.

Report severity

73.0%Serious9,116 reports
24.3%Hospitalizations3,041 reports
29.8%Fatal3,719 reports

Seriousness is determined by the reporter, not by OpenClaim.

Crizotinib drug interactions

Other drugs that appear in adverse event reports alongside crizotinib. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Alectinib-hydrochloride3.0%377
2
Pemetrexed2.2%281
3
Carboplatin1.9%240
4
Ceritinib1.7%218
5
Cyclophosphamide1.7%211
6
Dexamethasone1.6%202
7
Bevacizumab1.6%202
8
Doxorubicin-hydrochloride1.2%150
9
Cisplatin1.2%148
10
Erlotinib-hydrochloride1.2%145
11
Methotrexate1.1%143
12
Osimertinib-mesylate1.1%138
13
Etoposide0.9%114
14
Paclitaxel0.9%107
15
Ifosfamide0.8%102

Taken alongside

1
Ondansetron3.1%391
2
Acetaminophen2.8%346
3
Dexamethasone2.5%315
4
Oxycodone2.4%300
5
Furosemide2.2%271
6
Omeprazole2.2%271
7
Levothyroxine-sodium2.0%244
8
Aspirin1.8%221
9
Pantoprazole-sodium1.6%195
10
Lorazepam1.5%190
11
Ergocalciferol1.5%188
12
Atorvastatin-calcium1.4%171
13
Folic-acid1.3%167
14
Prochlorperazine1.3%167
15
Albuterol1.3%165

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports crizotinib side effects

49.0% of crizotinib adverse event reports involve female patients and 40.3% involve male patients. The largest age group is adult at 53%. These figures reflect who reports side effects, not underlying risk.

Sex

Female49.0%
Male40.3%
Unknown10.7%

Age group

< 20.3%
2–112.5%
12–172.0%
18–6453.1%
65+42.2%

What is crizotinib used for

Conditions and purposes for which patients were taking crizotinib when the adverse event was reported.

Acute Lymphocytic LeukaemiaAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma MetastaticAdenocarcinoma Of ColonAdenocarcinoma Of LungAdenocarcinoma Of Salivary GlandAdenocarcinoma PancreasAdenoid Cystic CarcinomaAdenosquamous Cell CarcinomaAdenosquamous Cell Lung CancerAdrenal Gland CancerAdrenal Gland Cancer MetastaticAdult T-cell Lymphoma/leukaemia Stage Iv

Showing 15 of 449 indications

Crizotinib brand names and reporting trend

Crizotinib is sold under the brand name Xalkori.

Brand names

Xalkori5,323

Quarterly reports (20112025)

20122016202020242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking crizotinib with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.