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Crizanlizumab Side Effects

The most commonly reported side effects of crizanlizumab include sickle cell anaemia with crisis, pain, and back pain, based on 1,393 FDA adverse event reports from 2019 to 2025. 5.7% of reports found the drug to be ineffective.

Crizanlizumab side effects

Percentages show how often each reaction appears relative to total reports for crizanlizumab.

1
Sickle Cell Anaemia With Crisis26.6%370
2
Pain25.6%356
3
Back Pain10.8%150
4
Infusion Related Reaction9.6%134
5
Arthralgia6.8%95
6
Pain In Extremity6.4%89
7
Nausea5.8%81
8
Chest Pain5.8%81
9
Drug Ineffective5.7%79
10
Pyrexia5.5%76
11
Headache5.1%71
12
Fatigue4.9%68
13
Acute Chest Syndrome3.9%54
14
Haemoglobin Decreased3.7%51
15
Product Dose Omission Issue3.2%44

These are voluntary reports and do not establish that crizanlizumab caused these reactions.

Report severity

54.7%Serious762 reports
41.3%Hospitalizations576 reports
3.9%Fatal54 reports

Seriousness is determined by the reporter, not by OpenClaim.

Crizanlizumab drug interactions

Other drugs that appear in adverse event reports alongside crizanlizumab. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Voxelotor8.2%114
2
L-glutamine1.4%19
3
Deferasirox0.9%12
4
Hydroxyurea0.6%8
5
Ketorolac-tromethamine0.3%4
6
Apomorphine-hydrochloride0.2%3
7
Dasatinib0.2%3
8
Diphenhydramine0.1%2
9
Ondansetron0.1%2
10
Ammonium0.1%2
11
Acetaminophen0.1%2
12
Medroxyprogesterone-acetate0.1%2
13
Deferiprone0.1%2
14
Deferoxamine-mesylate0.1%2
15
Methadone-hydrochloride<0.1%1

Taken alongside

1
Hydroxyurea12.3%172
2
Folic-acid8.3%116
3
Oxycodone5.0%70
4
Acetaminophen4.2%59
5
Ibuprofen3.4%47
6
Diphenhydramine3.3%46
7
Ergocalciferol3.2%45
8
Gabapentin2.7%38
9
Hydromorphone-hydrochloride2.1%29
10
Morphine-sulfate2.1%29
11
Sodium-chloride2.0%28
12
Deferasirox1.8%25
13
Ondansetron1.8%25
14
L-glutamine1.7%23
15
Famotidine1.6%22

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports crizanlizumab side effects

50.5% of crizanlizumab adverse event reports involve female patients and 31.4% involve male patients. The largest age group is adult at 88%. These figures reflect who reports side effects, not underlying risk.

Sex

Female50.5%
Male31.4%
Unknown18.0%

Age group

< 20.4%
2–110.4%
12–1710.6%
18–6487.8%
65+0.7%

What is crizanlizumab used for

Conditions and purposes for which patients were taking crizanlizumab when the adverse event was reported.

Brain Stem GliomaCardiovascular Event ProphylaxisCerebral InfarctionChronic Kidney DiseaseDeep Vein ThrombosisDouble Heterozygous Sickling DisordersExposure To Communicable DiseaseFoetal Exposure During PregnancyGlioblastomaGlioblastomaHaemochromatosisHaemoglobin C DiseaseHaemoglobinopathyHip ArthroplastyIron Deficiency

Showing 15 of 40 indications

Crizanlizumab brand names and reporting trend

Crizanlizumab is sold under the brand name Adakveo.

Brand names

Adakveo209

Quarterly reports (20192025)

2020202220242025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking crizanlizumab with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.