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Crinecerfont Side Effects

The most commonly reported side effects of crinecerfont include headache, fatigue, and epistaxis, based on 120 FDA adverse event reports from 2025 to 2025. 3.3% of reports found the drug to be ineffective.

Crinecerfont side effects

Percentages show how often each reaction appears relative to total reports for crinecerfont.

1
Headache13.3%16
2
Fatigue13.3%16
3
Epistaxis11.7%14
4
Weight Decreased8.3%10
5
Therapeutic Response Unexpected6.7%8
6
Dizziness5.8%7
7
17-hydroxyprogesterone Increased5.8%7
8
Laboratory Test Abnormal4.2%5
9
Blood Androstenedione Increased4.2%5
10
Vomiting4.2%5
11
Malaise3.3%4
12
Abdominal Pain3.3%4
13
Suicidal Ideation3.3%4
14
Anxiety3.3%4
15
Renin Increased3.3%4

These are voluntary reports and do not establish that crinecerfont caused these reactions.

Report severity

20.8%Serious25 reports
5.8%Hospitalizations7 reports
0.0%Fatal0 reports

Seriousness is determined by the reporter, not by OpenClaim.

Crinecerfont drug interactions

Other drugs that appear in adverse event reports alongside crinecerfont. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Hydrocortisone5.8%7
2
Dexamethasone3.3%4
3
Fludrocortisone-acetate3.3%4
4
Prednisone1.7%2
5
Amlodipine0.8%1
6
Ondansetron0.8%1
7
Abaloparatide0.8%1

Taken alongside

1
Hydrocortisone25.8%31
2
Fludrocortisone-acetate19.2%23
3
Prednisone8.3%10
4
Ergocalciferol4.2%5
5
Sertraline-hydrochloride3.3%4
6
Ondansetron3.3%4
7
Dexamethasone2.5%3
8
Lamotrigine2.5%3
9
Anastrozole1.7%2
10
Clonazepam1.7%2
11
Spironolactone1.7%2
12
Methylprednisolone1.7%2
13
Pantoprazole-sodium1.7%2
14
L-glutamine0.8%1
15
Mesalamine0.8%1

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports crinecerfont side effects

31.7% of crinecerfont adverse event reports involve female patients and 45.8% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female31.7%
Male45.8%
Unknown22.5%

Age group

< 20.0%
2–1126.4%
12–1715.3%
18–6458.3%
65+0.0%

What is crinecerfont used for

Conditions and purposes for which patients were taking crinecerfont when the adverse event was reported.

Adrenogenital SyndromeAndrogen TherapyProduct Used For Unknown Indication

Crinecerfont brand names and reporting trend

Crinecerfont is sold under the brand name Crenessity.

Brand names

Crenessity5

Quarterly reports (20252025)

20252025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking crinecerfont with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.