OpenClaim

Cosyntropin Side Effects

The most commonly reported side effects of cosyntropin include foetal growth restriction, foetal exposure during pregnancy, and dyspnoea, based on 266 FDA adverse event reports from 2004 to 2025. 5.3% of reports found the drug to be ineffective.

Cosyntropin side effects

Percentages show how often each reaction appears relative to total reports for cosyntropin.

1
Foetal Growth Restriction7.5%20
2
Foetal Exposure During Pregnancy7.5%20
3
Dyspnoea6.4%17
4
Hypoglycaemia5.6%15
5
Drug Ineffective5.3%14
6
Hypotension4.5%12
7
Nausea4.1%11
8
Rash3.8%10
9
Adrenal Insufficiency3.8%10
10
Pneumonia3.8%10
11
Off Label Use3.8%10
12
Hyperkalaemia3.4%9
13
Pneumonia2.6%7
14
Hypertension2.6%7
15
Sepsis2.6%7

These are voluntary reports and do not establish that cosyntropin caused these reactions.

Report severity

85.7%Serious228 reports
41.7%Hospitalizations111 reports
12.0%Fatal32 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cosyntropin drug interactions

Other drugs that appear in adverse event reports alongside cosyntropin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Ondansetron9.8%26
2
Pantoprazole-sodium9.4%25
3
Insulin8.6%23
4
Hydromorphone-hydrochloride8.3%22
5
Oxazepam7.9%21
6
Hydroxyzine7.9%21
7
Sumatriptan7.9%21
8
Diphenhydramine7.9%21
9
Metoclopramide-hydrochloride7.9%21
10
Aspirin7.5%20
11
Thiamine7.5%20
12
Pimozide6.8%18
13
Ipilimumab5.3%14
14
Nivolumab4.9%13
15
Vigabatrin4.1%11

Taken alongside

1
Acetaminophen24.8%66
2
Ondansetron19.9%53
3
Hydrocortisone18.4%49
4
Sodium-chloride15.8%42
5
Aspirin15.8%42
6
Albuterol15.8%42
7
Omeprazole15.4%41
8
Pantoprazole-sodium15.0%40
9
Furosemide14.3%38
10
Diphenhydramine14.3%38
11
Potassium-chloride14.3%38
12
Lorazepam13.9%37
13
Oxycodone13.9%37
14
Levothyroxine-sodium13.2%35
15
Lidocaine12.8%34

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cosyntropin side effects

48.9% of cosyntropin adverse event reports involve female patients and 37.6% involve male patients. The largest age group is adult at 46%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.9%
Male37.6%
Unknown13.5%

Age group

< 216.7%
2–115.4%
12–173.9%
18–6446.3%
65+27.6%

What is cosyntropin used for

Conditions and purposes for which patients were taking cosyntropin when the adverse event was reported.

Acth Stimulation TestActh Stimulation TestAddison's DiseaseAdrenal DisorderAdrenal InsufficiencyAdrenocortical Insufficiency AcuteAdrenocortical Insufficiency ChronicAdrenocortical Steroid TherapyAdrenal InsufficiencyAutoimmune ThyroiditisBiopsy Adrenal GlandBlood CorticotrophinBlood CortisolBlood CorticotrophinBlood Cortisol

Showing 15 of 49 indications

Cosyntropin brand names and reporting trend

Cosyntropin is sold under the brand name Cosyntropin.

Brand names

Cosyntropin217

Quarterly reports (20042025)

2004201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cosyntropin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.