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Corticotropin Side Effects

The most commonly reported side effects of corticotropin include fatigue, injection site bruising, and insomnia, based on 9,699 FDA adverse event reports from 2004 to 2025. 6.5% of reports found the drug to be ineffective.

Corticotropin side effects

Percentages show how often each reaction appears relative to total reports for corticotropin.

1
Fatigue7.6%736
2
Injection Site Bruising6.5%633
3
Drug Ineffective6.5%626
4
Insomnia6.0%579
5
Product Dose Omission Issue5.9%574
6
Injection Site Pain5.7%557
7
Headache5.0%486
8
Pain4.6%442
9
Weight Increased4.2%409
10
Condition Aggravated4.1%399
11
Peripheral Swelling3.8%368
12
Blood Glucose Increased3.8%366
13
Contraindicated Product Administered3.5%337
14
Asthenia3.4%327
15
Hypertension3.2%309

These are voluntary reports and do not establish that corticotropin caused these reactions.

Report severity

46.7%Serious4,534 reports
15.5%Hospitalizations1,502 reports
3.1%Fatal302 reports

Seriousness is determined by the reporter, not by OpenClaim.

Corticotropin drug interactions

Other drugs that appear in adverse event reports alongside corticotropin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Vigabatrin4.4%426
2
Prednisone2.8%275
3
Levetiracetam1.4%132
4
Epcoritamab-bysp1.2%114
5
Topiramate1.1%109
6
Rituximab0.9%88
7
Methotrexate0.8%79
8
Clonazepam0.8%77
9
Dalfampridine0.8%74
10
Phenobarbital-sodium0.7%72
11
Valproic-acid0.7%70
12
Mycophenolate0.6%62
13
Adalimumab0.6%61
14
Prednisolone0.6%60
15
Carbamazepine0.6%59

Taken alongside

1
Prednisone7.7%749
2
Ergocalciferol5.7%557
3
Acetaminophen4.1%402
4
Gabapentin3.4%332
5
Levothyroxine-sodium3.4%330
6
Methotrexate3.4%325
7
Atorvastatin-calcium3.3%324
8
Metoprolol3.2%307
9
Aspirin3.1%300
10
Amlodipine2.7%266
11
Folic-acid2.7%263
12
Omeprazole2.6%252
13
Losartan-potassium2.5%247
14
Albuterol2.5%244
15
Furosemide2.4%235

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports corticotropin side effects

64.8% of corticotropin adverse event reports involve female patients and 32.8% involve male patients. The largest age group is adult at 56%. These figures reflect who reports side effects, not underlying risk.

Sex

Female64.8%
Male32.8%
Unknown2.4%

Age group

< 28.3%
2–112.2%
12–170.3%
18–6456.4%
65+32.8%

What is corticotropin used for

Conditions and purposes for which patients were taking corticotropin when the adverse event was reported.

Acth Stimulation TestAcute Lymphocytic LeukaemiaAdrenal InsufficiencyAnkylosing SpondylitisAnorexiaAntinuclear AntibodyArthritisAsbestosisAstheniaAsthmaAddison^s DiseaseAdrenal DisorderAdrenal InsufficiencyAdverse Drug ReactionAllergic Keratitis

Showing 15 of 404 indications

Corticotropin brand names and reporting trend

Corticotropin is sold under brand names including Corticotropin, Cortrophin-zinc.

Brand names

Corticotropin12,026
Cortrophin-zinc13

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking corticotropin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.