OpenClaim

Copper Side Effects

The most commonly reported side effects of copper include device expulsion, device breakage, and complication of device removal, based on 43,101 FDA adverse event reports from 2004 to 2025. 3.4% of reports found the drug to be ineffective.

#1 Reported: Device ExpulsionAll side effects ↓Top Co-Medication: Sodium-oxybateDrug interactions ↓94% of Reports Are AdultDemographics ↓

Copper side effects

Percentages show how often each reaction appears relative to total reports for copper.

1
Device Expulsion24.6%10,603
2
Device Breakage21.8%9,375
3
Complication Of Device Removal19.1%8,219
4
Foreign Body In Reproductive Tract16.9%7,285
5
Device Dislocation15.5%6,696
6
Complication Of Device Insertion14.1%6,071
7
Pain12.5%5,398
8
Reproductive Complication Associated With Device8.7%3,764
9
Embedded Device8.4%3,609
10
Injury Associated With Device6.6%2,852
11
Anxiety6.1%2,612
12
Muscle Spasms5.0%2,136
13
Off Label Use4.9%2,130
14
Emotional Distress4.8%2,052
15
Pelvic Pain4.5%1,958

These are voluntary reports and do not establish that copper caused these reactions.

Report severity

42.3%Serious18,227 reports
2.3%Hospitalizations997 reports
0.2%Fatal97 reports

Seriousness is determined by the reporter, not by OpenClaim.

Copper drug interactions

Other drugs that appear in adverse event reports alongside copper. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Sodium-oxybate0.3%108
2
Levonorgestrel0.2%103
3
Teduglutide0.1%53
4
Ergocalciferol0.1%51
5
Lenalidomide0.1%48
6
Ascorbic-acid0.1%46
7
Adalimumab0.1%45
8
Zinc-sulfate<0.1%40
9
Cyanocobalamin<0.1%39
10
Folic-acid<0.1%36
11
Selenium-sulfide<0.1%36
12
Buspirone-hydrochloride<0.1%32
13
Ethinyl-estradiol<0.1%32
14
Vitamin-e<0.1%31
15
Vitamin-a<0.1%31

Taken alongside

1
Ergocalciferol2.9%1,259
2
Levothyroxine-sodium2.5%1,069
3
Sertraline-hydrochloride1.7%754
4
Albuterol1.4%618
5
Buspirone-hydrochloride1.4%600
6
Bupropion1.2%529
7
Escitalopram-oxalate1.2%507
8
Dextroamphetamine1.0%452
9
Ascorbic-acid1.0%443
10
Ibuprofen1.0%439
11
Acetaminophen1.0%436
12
Amphetamine1.0%429
13
Cyanocobalamin1.0%428
14
Fluoxetine-hydrochloride1.0%426
15
Calcium1.0%419

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports copper side effects

84.9% of copper adverse event reports involve female patients and 3.7% involve male patients. The largest age group is adult at 94%. These figures reflect who reports side effects, not underlying risk.

Sex

Female84.9%
Male3.7%
Unknown11.4%

Age group

< 20.5%
2–111.7%
12–172.0%
18–6494.1%
65+1.8%

What is copper used for

Conditions and purposes for which patients were taking copper when the adverse event was reported.

Abdominal DiscomfortAccidental ExposureAnaemiaAndrogenetic AlopeciaAsherman's SyndromeAutoimmune DisorderAbnormal Uterine BleedingAmenorrhoeaAnaemiaAstrocytoma MalignantAtrial FibrillationBasal Cell CarcinomaBirth ControlBlood Copper DecreasedBone Disorder

Showing 15 of 151 indications

Copper brand names and reporting trend

Copper is sold under brand names including Tatum-t, Zycubo.

Brand names

Tatum-t5,597
Zycubo1

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking copper with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.

Check my medications