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Conjugated Side Effects

The most commonly reported side effects of conjugated include foetal exposure during pregnancy, fatigue, and nausea, based on 580 FDA adverse event reports from 2004 to 2025. 5.3% of reports found the drug to be ineffective.

Conjugated side effects

Percentages show how often each reaction appears relative to total reports for conjugated.

1
Foetal Exposure During Pregnancy7.6%44
2
Fatigue6.4%37
3
Drug Ineffective5.3%31
4
Nausea5.2%30
5
Pain4.5%26
6
Diarrhoea4.0%23
7
Dyspnoea3.8%22
8
Off Label Use3.8%22
9
Breast Cancer Metastatic3.4%20
10
Headache3.4%20
11
Arthralgia3.3%19
12
Exposure During Pregnancy3.3%19
13
Malaise2.8%16
14
Pruritus2.8%16
15
Dizziness2.8%16

These are voluntary reports and do not establish that conjugated caused these reactions.

Report severity

71.2%Serious413 reports
23.4%Hospitalizations136 reports
1.7%Fatal10 reports

Seriousness is determined by the reporter, not by OpenClaim.

Conjugated drug interactions

Other drugs that appear in adverse event reports alongside conjugated. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Estrogens5.0%29
2
Estradiol4.5%26
3
Medroxyprogesterone-acetate4.0%23
4
Citalopram-hydrobromide3.6%21
5
Apremilast3.4%20
6
Esomeprazole3.1%18
7
Etanercept2.9%17
8
Adalimumab2.9%17
9
Lamotrigine2.9%17
10
Omeprazole2.8%16
11
Pantoprazole-sodium2.4%14
12
Lansoprazole2.1%12
13
Certolizumab-pegol1.9%11
14
Amitriptyline-hydrochloride1.9%11
15
Sodium-oxybate1.9%11

Taken alongside

1
Estradiol16.4%95
2
Levothyroxine-sodium15.2%88
3
Ergocalciferol12.6%73
4
Acetaminophen11.2%65
5
Fluticasone8.6%50
6
Aspirin8.4%49
7
Albuterol8.3%48
8
Calcium8.1%47
9
Gabapentin7.6%44
10
Prednisone7.4%43
11
Lisinopril7.1%41
12
Omeprazole7.1%41
13
Folic-acid6.4%37
14
Furosemide6.0%35
15
Estrogens5.9%34

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports conjugated side effects

83.6% of conjugated adverse event reports involve female patients and 8.4% involve male patients. The largest age group is adult at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female83.6%
Male8.4%
Unknown7.9%

Age group

< 211.7%
2–110.3%
12–170.0%
18–6474.6%
65+13.5%

What is conjugated used for

Conditions and purposes for which patients were taking conjugated when the adverse event was reported.

Abortion ThreatenedAnticoagulant TherapyAssisted FertilisationAssisted Reproductive TechnologyAntiallergic TherapyBlood Follicle Stimulating Hormone DecreasedBlood Luteinising Hormone DecreasedBlood Oestrogen IncreasedBreast CancerCardiac DisorderContraceptionDrug DependenceDrug Use For Unknown IndicationDysmenorrhoeaEpilepsy

Showing 15 of 55 indications

Conjugated brand names and reporting trend

Conjugated is sold under the brand name Prempro/premphase.

Brand names

Prempro/premphase562

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking conjugated with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.