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Cocaine Side Effects

The most commonly reported side effects of cocaine include drug abuse, toxicity to various agents, and death, based on 19,440 FDA adverse event reports from 2004 to 2025.

Cocaine side effects

Percentages show how often each reaction appears relative to total reports for cocaine.

1
Drug Abuse34.3%6,672
2
Toxicity To Various Agents19.1%3,714
3
Death7.4%1,446
4
Drug Dependence6.8%1,317
5
Overdose6.0%1,173
6
Substance Use Disorder5.8%1,133
7
Completed Suicide5.6%1,097
8
Drug Use Disorder5.4%1,043
9
Substance Abuse5.3%1,037
10
Coma5.0%978
11
Cardiac Arrest4.5%870
12
Cardio-respiratory Arrest4.5%868
13
Intentional Product Misuse4.4%854
14
Respiratory Arrest3.6%695
15
Poisoning3.4%655

These are voluntary reports and do not establish that cocaine caused these reactions.

Report severity

98.2%Serious19,086 reports
26.5%Hospitalizations5,161 reports
56.7%Fatal11,024 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cocaine drug interactions

Other drugs that appear in adverse event reports alongside cocaine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Fentanyl18.1%3,517
2
Diazepam16.3%3,172
3
Oxycodone16.0%3,117
4
Alcohol13.9%2,693
5
Methadone-hydrochloride13.8%2,692
6
Alprazolam13.8%2,684
7
Acetaminophen11.0%2,138
8
Amphetamine10.3%1,998
9
Pregabalin8.7%1,686
10
Buprenorphine7.5%1,465
11
Tramadol-hydrochloride7.1%1,386
12
Clonazepam6.5%1,269
13
Morphine-sulfate6.3%1,223
14
Apomorphine-hydrochloride6.1%1,187
15
Quetiapine-fumarate5.8%1,136

Taken alongside

1
Diazepam1.0%203
2
Amphetamine1.0%197
3
Acetaminophen1.0%195
4
Alcohol0.9%176
5
Methadone-hydrochloride0.8%147
6
Alprazolam0.7%129
7
Gabapentin0.6%125
8
Clonazepam0.5%102
9
Quetiapine-fumarate0.5%98
10
Oxycodone0.5%93
11
Ibuprofen0.5%89
12
Buprenorphine0.4%84
13
Lorazepam0.4%79
14
Fentanyl0.4%79
15
Apomorphine-hydrochloride0.4%76

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cocaine side effects

29.9% of cocaine adverse event reports involve female patients and 60.5% involve male patients. The largest age group is adult at 95%. These figures reflect who reports side effects, not underlying risk.

Sex

Female29.9%
Male60.5%
Unknown9.6%

Age group

< 21.1%
2–110.2%
12–172.4%
18–6494.9%
65+1.4%

What is cocaine used for

Conditions and purposes for which patients were taking cocaine when the adverse event was reported.

Abnormal BehaviourAccidental ExposureAccidental Exposure To ProductAggressionAgitationAnaesthesiaAnalgesic TherapyAnxietyArthralgiaAccidental Exposure To ProductAffective DisorderAnaesthesia OralAnalgesic TherapyAnxietyAnxiolytic Therapy

Showing 15 of 136 indications

Cocaine brand names and reporting trend

Cocaine is sold under the brand name Goprelto.

Brand names

Goprelto20,523

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cocaine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.