OpenClaim

Cobicistat Side Effects

The most commonly reported side effects of cobicistat include bone density decreased, chronic kidney disease, and renal injury, based on 20,703 FDA adverse event reports from 2007 to 2025.

Cobicistat side effects

Percentages show how often each reaction appears relative to total reports for cobicistat.

1
Bone Density Decreased38.8%8,041
2
Chronic Kidney Disease22.8%4,710
3
Renal Injury22.1%4,576
4
Tooth Loss20.0%4,140
5
Bone Loss19.7%4,080
6
Skeletal Injury19.7%4,077
7
Osteonecrosis19.5%4,033
8
Renal Failure18.5%3,829
9
Multiple Fractures17.9%3,701
10
Pain16.9%3,507
11
Emotional Distress16.4%3,400
12
Osteoporosis16.2%3,347
13
Anxiety15.3%3,175
14
Anhedonia14.6%3,013
15
Osteopenia9.9%2,055

These are voluntary reports and do not establish that cobicistat caused these reactions.

Report severity

78.1%Serious16,166 reports
12.0%Hospitalizations2,482 reports
2.8%Fatal585 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cobicistat drug interactions

Other drugs that appear in adverse event reports alongside cobicistat. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Tenofovir87.1%18,036
2
Emtricitabine86.2%17,850
3
Elvitegravir55.6%11,514
4
Efavirenz33.1%6,861
5
Rilpivirine18.3%3,796
6
Darunavir10.9%2,250
7
Dolutegravir3.1%643
8
Lamivudine2.0%415
9
Ritonavir1.8%379
10
Abacavir1.5%303
11
Atazanavir-sulfate1.3%272
12
Bictegravir1.0%212
13
Raltegravir-potassium0.9%177
14
Cabotegravir0.6%127
15
Lopinavir0.6%117

Taken alongside

1
Tenofovir52.5%10,872
2
Emtricitabine52.5%10,870
3
Elvitegravir34.7%7,179
4
Bictegravir18.9%3,923
5
Darunavir13.1%2,716
6
Dolutegravir5.2%1,068
7
Ritonavir4.5%941
8
Lamivudine4.4%918
9
Rilpivirine3.9%798
10
Acetaminophen3.2%658
11
Abacavir3.0%629
12
Ergocalciferol3.0%612
13
Atorvastatin-calcium2.9%592
14
Albuterol2.8%584
15
Aspirin2.6%548

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cobicistat side effects

23.3% of cobicistat adverse event reports involve female patients and 66.9% involve male patients. The largest age group is adult at 93%. These figures reflect who reports side effects, not underlying risk.

Sex

Female23.3%
Male66.9%
Unknown9.8%

Age group

< 20.6%
2–11<0.1%
12–170.2%
18–6492.9%
65+6.3%

What is cobicistat used for

Conditions and purposes for which patients were taking cobicistat when the adverse event was reported.

Acquired Immunodeficiency SyndromeAcute Hepatitis CAcute Hiv InfectionAnal CancerAnogenital WartsAntiretroviral TherapyAntiviral TreatmentArthralgiaAsymptomatic Hiv InfectionAcquired Immunodeficiency SyndromeAcute Hiv InfectionAntiretroviral TherapyAntiviral TreatmentAsymptomatic Hiv InfectionBacillary Angiomatosis

Showing 15 of 110 indications

Cobicistat brand names and reporting trend

Cobicistat is sold under the brand name Symtuza.

Brand names

Symtuza688

Quarterly reports (20072025)

2007201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cobicistat with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.