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Clotrimazole Side Effects

The most commonly reported side effects of clotrimazole include nausea, pain, and off label use, based on 15,709 FDA adverse event reports from 2004 to 2025. 10.3% of reports found the drug to be ineffective.

Clotrimazole side effects

Percentages show how often each reaction appears relative to total reports for clotrimazole.

1
Drug Ineffective10.3%1,614
2
Nausea5.7%890
3
Pain5.7%888
4
Off Label Use5.5%858
5
Fatigue5.1%808
6
Macular Degeneration5.1%803
7
Headache5.0%790
8
Dyspnoea4.8%747
9
Diarrhoea4.4%695
10
Chronic Kidney Disease3.4%538
11
Rash3.4%534
12
Pyrexia3.4%534
13
Acute Kidney Injury3.3%525
14
Weight Decreased3.3%521
15
Malaise3.3%517

These are voluntary reports and do not establish that clotrimazole caused these reactions.

Report severity

72.8%Serious11,434 reports
33.8%Hospitalizations5,314 reports
8.4%Fatal1,323 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clotrimazole drug interactions

Other drugs that appear in adverse event reports alongside clotrimazole. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Prednisone8.1%1,265
2
Betamethasone7.4%1,168
3
Acetaminophen7.1%1,122
4
Pantoprazole-sodium7.1%1,112
5
Azithromycin6.6%1,038
6
Fluticasone6.4%1,011
7
Adalimumab6.3%988
8
Amoxicillin6.2%980
9
Budesonide6.2%975
10
Ergocalciferol6.1%953
11
Clarithromycin5.9%925
12
Metronidazole5.9%922
13
Hydrochlorothiazide5.7%892
14
Triamcinolone5.6%876
15
Pregabalin5.5%865

Taken alongside

1
Acetaminophen26.3%4,136
2
Albuterol19.6%3,084
3
Aspirin18.0%2,824
4
Ergocalciferol15.8%2,487
5
Omeprazole15.7%2,473
6
Furosemide15.3%2,407
7
Fluticasone14.5%2,281
8
Betamethasone13.9%2,179
9
Prednisone13.6%2,134
10
Levothyroxine-sodium12.9%2,034
11
Gabapentin12.8%2,011
12
Atorvastatin-calcium12.7%1,990
13
Ondansetron11.9%1,862
14
Amlodipine11.3%1,768
15
Pantoprazole-sodium11.0%1,732

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clotrimazole side effects

57.5% of clotrimazole adverse event reports involve female patients and 33.8% involve male patients. The largest age group is adult at 52%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.5%
Male33.8%
Unknown8.8%

Age group

< 21.4%
2–111.9%
12–171.4%
18–6452.5%
65+42.9%

What is clotrimazole used for

Conditions and purposes for which patients were taking clotrimazole when the adverse event was reported.

Abdominal PainAcneAcne InfantileAcrokeratosis ParaneoplasticaAcute Haemorrhagic Oedema Of InfancyAcute Lymphocytic LeukaemiaAcute Respiratory FailureAdverse EventAnal CandidiasisAnal FistulaAnal Fungal InfectionAnal InfectionAnal PruritusAngina PectorisAngioedema

Showing 15 of 497 indications

Clotrimazole brand names and reporting trend

Clotrimazole is sold under the brand name Trivagizole 3.

Brand names

Trivagizole 313,230

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clotrimazole with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.