OpenClaim

Clorazepate Side Effects

The most commonly reported side effects of clorazepate include coma, somnolence, and off label use, based on 5,681 FDA adverse event reports from 2004 to 2025. 3.2% of reports found the drug to be ineffective.

Clorazepate side effects

Percentages show how often each reaction appears relative to total reports for clorazepate.

1
Coma4.7%265
2
Somnolence4.1%231
3
Off Label Use3.7%208
4
Fall3.3%185
5
Drug Ineffective3.2%184
6
Diarrhoea3.2%180
7
Toxicity To Various Agents3.1%177
8
Nausea3.0%168
9
Fatigue2.7%155
10
Vomiting2.7%151
11
Confusional State2.6%147
12
Acute Kidney Injury2.6%146
13
Drug Interaction2.5%141
14
Hypotension2.4%137
15
Anxiety2.4%135

These are voluntary reports and do not establish that clorazepate caused these reactions.

Report severity

85.9%Serious4,882 reports
52.5%Hospitalizations2,984 reports
10.8%Fatal612 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clorazepate drug interactions

Other drugs that appear in adverse event reports alongside clorazepate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Acetaminophen5.4%308
2
Olanzapine5.3%299
3
Venlafaxine4.5%254
4
Aripiprazole4.4%248
5
Risperidone4.2%236
6
Diazepam4.1%235
7
Haloperidol3.7%211
8
Alprazolam3.4%194
9
Quetiapine-fumarate3.2%183
10
Pregabalin2.7%153
11
Levetiracetam2.5%143
12
Fluoxetine-hydrochloride2.5%141
13
Pantoprazole-sodium2.4%137
14
Ibuprofen2.3%129
15
Furosemide2.2%127

Taken alongside

1
Acetaminophen10.6%603
2
Levothyroxine-sodium8.2%468
3
Omeprazole7.1%403
4
Aspirin6.0%343
5
Atorvastatin-calcium4.8%270
6
Furosemide4.8%270
7
Albuterol4.7%265
8
Pantoprazole-sodium4.5%258
9
Hydrochlorothiazide4.2%240
10
Esomeprazole4.0%227
11
Metformin3.7%212
12
Ergocalciferol3.7%210
13
Gabapentin3.5%198
14
Prednisone3.3%190
15
Potassium-chloride3.3%190

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clorazepate side effects

57.6% of clorazepate adverse event reports involve female patients and 36.3% involve male patients. The largest age group is adult at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.6%
Male36.3%
Unknown6.1%

Age group

< 21.0%
2–112.5%
12–172.1%
18–6462.9%
65+31.5%

What is clorazepate used for

Conditions and purposes for which patients were taking clorazepate when the adverse event was reported.

Abdominal DiscomfortAbnormal BehaviourAggressionAgitationAlcohol Withdrawal SyndromeAlcoholismAngerAntidepressant TherapyAnxietyAnxiety DisorderAnxiety ReactionAnxiolytic TherapyAortic Valve ProlapseApathyAtrial Fibrillation

Showing 15 of 255 indications

Clorazepate brand names and reporting trend

Clorazepate is sold under the brand name Tranxene Sd.

Brand names

Tranxene Sd2,231

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clorazepate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.