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Clopidogrel Side Effects

The most commonly reported side effects of clopidogrel include gastrointestinal haemorrhage, myocardial infarction, and dyspnoea, based on 125,602 FDA adverse event reports from 2004 to 2025. 2.5% of reports found the drug to be ineffective.

Clopidogrel side effects

Percentages show how often each reaction appears relative to total reports for clopidogrel.

1
Gastrointestinal Haemorrhage4.7%5,850
2
Myocardial Infarction3.8%4,815
3
Dyspnoea3.4%4,269
4
Fatigue3.2%3,984
5
Diarrhoea2.8%3,479
6
Nausea2.6%3,321
7
Drug Ineffective2.5%3,125
8
Cerebrovascular Accident2.4%3,039
9
Dizziness2.4%2,993
10
Asthenia2.4%2,975
11
Off Label Use2.3%2,885
12
Myocardial Infarction2.2%2,786
13
Death2.2%2,783
14
Fall2.2%2,780
15
Acute Kidney Injury2.1%2,634

These are voluntary reports and do not establish that clopidogrel caused these reactions.

Report severity

78.6%Serious98,776 reports
45.4%Hospitalizations57,018 reports
11.3%Fatal14,237 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clopidogrel drug interactions

Other drugs that appear in adverse event reports alongside clopidogrel. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aspirin9.2%11,601
2
Rivaroxaban4.1%5,093
3
Rosiglitazone-maleate3.7%4,644
4
Atorvastatin-calcium2.7%3,432
5
Lenalidomide2.4%3,008
6
Esomeprazole2.2%2,817
7
Apixaban2.1%2,674
8
Metformin2.1%2,594
9
Omeprazole2.0%2,527
10
Rosuvastatin2.0%2,506
11
Adalimumab2.0%2,502
12
Niacin2.0%2,466
13
Pantoprazole-sodium1.8%2,308
14
Insulin1.6%1,997
15
Warfarin1.5%1,884

Taken alongside

1
Aspirin33.1%41,534
2
Atorvastatin-calcium18.2%22,910
3
Metoprolol17.6%22,156
4
Furosemide14.7%18,507
5
Amlodipine11.5%14,504
6
Lisinopril11.2%14,012
7
Simvastatin10.5%13,195
8
Acetaminophen10.4%13,107
9
Levothyroxine-sodium9.4%11,830
10
Insulin9.3%11,654
11
Metformin9.1%11,374
12
Carvedilol8.0%10,106
13
Rosuvastatin8.0%10,058
14
Nitroglycerin7.9%9,909
15
Ergocalciferol7.9%9,878

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clopidogrel side effects

41.2% of clopidogrel adverse event reports involve female patients and 51.8% involve male patients. The largest age group is elderly at 65%. These figures reflect who reports side effects, not underlying risk.

Sex

Female41.2%
Male51.8%
Unknown7.0%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6435.2%
65+64.6%

What is clopidogrel used for

Conditions and purposes for which patients were taking clopidogrel when the adverse event was reported.

Abdominal DiscomfortAbnormal Clotting FactorAccidental ExposureAccidental Exposure To Product By ChildAcute Coronary SyndromeAcute Myocardial InfarctionAdenocarcinoma PancreasAdjuvant TherapyAdverse EventAfibAge Indeterminate Myocardial InfarctionAmaurosis FugaxAmnesiaAnaemiaAnalgesic Therapy

Showing 15 of 1,182 indications

Clopidogrel brand names and reporting trend

Clopidogrel is sold under the brand name Plavix.

Brand names

Plavix16,373

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clopidogrel with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.