OpenClaim

Clomipramine Side Effects

The most commonly reported side effects of clomipramine include toxicity to various agents, suicide attempt, and off label use, based on 9,684 FDA adverse event reports from 2004 to 2025. 8.3% of reports found the drug to be ineffective.

Clomipramine side effects

Percentages show how often each reaction appears relative to total reports for clomipramine.

1
Drug Ineffective8.3%806
2
Toxicity To Various Agents5.8%560
3
Suicide Attempt5.1%498
4
Off Label Use4.9%471
5
Drug Interaction4.6%446
6
Intentional Overdose3.3%324
7
Weight Increased3.3%320
8
Suicidal Ideation3.0%294
9
Somnolence3.0%292
10
Coma3.0%292
11
Condition Aggravated2.9%282
12
Tremor2.9%279
13
Anxiety2.8%268
14
Nausea2.6%249
15
Obsessive-compulsive Disorder2.5%246

These are voluntary reports and do not establish that clomipramine caused these reactions.

Report severity

91.6%Serious8,870 reports
50.3%Hospitalizations4,871 reports
11.4%Fatal1,100 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clomipramine drug interactions

Other drugs that appear in adverse event reports alongside clomipramine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate12.0%1,163
2
Olanzapine11.8%1,139
3
Aripiprazole8.7%845
4
Risperidone8.2%792
5
Clozapine7.1%686
6
Fluoxetine-hydrochloride6.4%615
7
Mirtazapine5.8%561
8
Venlafaxine5.8%559
9
Lithium5.1%495
10
Lorazepam5.0%486
11
Lamotrigine4.6%448
12
Gabapentin4.4%427
13
Sertraline-hydrochloride4.4%425
14
Paroxetine4.4%423
15
Haloperidol4.1%400

Taken alongside

1
Omeprazole5.2%499
2
Acetaminophen4.8%466
3
Levothyroxine-sodium4.6%450
4
Aspirin4.2%408
5
Clonazepam3.9%376
6
Lorazepam3.8%369
7
Quetiapine-fumarate3.7%363
8
Metformin3.7%360
9
Alprazolam3.5%340
10
Atorvastatin-calcium3.4%334
11
Gabapentin3.3%315
12
Diazepam3.2%312
13
Pantoprazole-sodium3.0%295
14
Olanzapine2.9%276
15
Fluoxetine-hydrochloride2.8%275

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clomipramine side effects

53.6% of clomipramine adverse event reports involve female patients and 38.4% involve male patients. The largest age group is adult at 67%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.6%
Male38.4%
Unknown8.1%

Age group

< 22.3%
2–110.8%
12–172.8%
18–6467.1%
65+27.0%

What is clomipramine used for

Conditions and purposes for which patients were taking clomipramine when the adverse event was reported.

22q11.2 Deletion SyndromeAbdominal Pain UpperAbnormal BehaviourAccidental ExposureAdjustment Disorder With AnxietyAdjustment Disorder With Depressed MoodAdjuvant TherapyAdverse EventAffective DisorderAggressionAgitationAgoraphobiaAlcohol AbuseAlcoholismAmnesia

Showing 15 of 333 indications

Clomipramine brand names and reporting trend

Clomipramine is sold under the brand name Anafranil.

Brand names

Anafranil251

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clomipramine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.