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Clofibrate Side Effects

The most commonly reported side effects of clofibrate include pain, off label use, and headache, based on 460 FDA adverse event reports from 2004 to 2025. 19.3% of reports found the drug to be ineffective.

Clofibrate side effects

Percentages show how often each reaction appears relative to total reports for clofibrate.

1
Pain23.5%108
2
Off Label Use22.8%105
3
Headache21.1%97
4
Nausea20.4%94
5
Malaise20.4%94
6
Pyrexia20.0%92
7
Anaemia19.6%90
8
Weight Decreased19.6%90
9
Drug Ineffective19.3%89
10
Dyspepsia18.9%87
11
Constipation18.7%86
12
Erythema18.7%86
13
Therapeutic Product Effect Incomplete18.7%86
14
Abdominal Pain18.5%85
15
Chronic Sinusitis18.5%85

These are voluntary reports and do not establish that clofibrate caused these reactions.

Report severity

75.2%Serious346 reports
49.3%Hospitalizations227 reports
7.0%Fatal32 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clofibrate drug interactions

Other drugs that appear in adverse event reports alongside clofibrate. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Atorvastatin-calcium21.7%100
2
Pantoprazole-sodium21.3%98
3
Pregabalin20.4%94
4
Alprazolam19.8%91
5
Clarithromycin19.8%91
6
Diphenhydramine19.6%90
7
Hydromorphone-hydrochloride19.6%90
8
Hydrochlorothiazide19.3%89
9
Fluticasone19.3%89
10
Acetaminophen19.3%89
11
Cetirizine-hydrochloride19.1%88
12
Metronidazole18.9%87
13
Nicotine18.9%87
14
Nadolol18.9%87
15
Adalimumab18.7%86

Taken alongside

1
Acetaminophen25.2%116
2
Ergocalciferol25.0%115
3
Aspirin21.1%97
4
Atorvastatin-calcium18.9%87
5
Levothyroxine-sodium18.5%85
6
Metformin18.0%83
7
Furosemide15.9%73
8
Lisinopril14.1%65
9
Insulin13.3%61
10
Omeprazole13.0%60
11
Fluticasone12.6%58
12
Valsartan12.4%57
13
Amlodipine12.0%55
14
Gabapentin11.7%54
15
Diphenhydramine10.7%49

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clofibrate side effects

61.3% of clofibrate adverse event reports involve female patients and 32.2% involve male patients. The largest age group is elderly at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female61.3%
Male32.2%
Unknown6.5%

Age group

< 20.0%
2–110.0%
12–171.4%
18–6438.3%
65+60.2%

What is clofibrate used for

Conditions and purposes for which patients were taking clofibrate when the adverse event was reported.

ArthritisB Precursor Type Acute LeukaemiaBlood CholesterolBlood Cholesterol AbnormalBlood Cholesterol DecreasedBlood Cholesterol IncreasedBlood TriglyceridesBlood Triglycerides IncreasedBlood Cholesterol IncreasedCongenital Generalised LipodystrophyConstipationComplex Regional Pain SyndromeDiabetes MellitusDrug Use For Unknown IndicationDyslipidaemia

Showing 15 of 28 indications

Clofibrate brand names and reporting trend

Clofibrate is sold under the brand name Clofibrate.

Brand names

Clofibrate481

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clofibrate with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.