OpenClaim

Clofarabine Side Effects

The most commonly reported side effects of clofarabine include febrile neutropenia, off label use, and febrile neutropenia, based on 3,181 FDA adverse event reports from 2004 to 2025. 6.0% of reports found the drug to be ineffective.

Clofarabine side effects

Percentages show how often each reaction appears relative to total reports for clofarabine.

1
Febrile Neutropenia7.2%230
2
Off Label Use6.7%213
3
Drug Ineffective6.0%191
4
Febrile Neutropenia5.5%176
5
Pyrexia5.3%168
6
Hypotension4.8%152
7
Sepsis4.5%142
8
Death3.7%119
9
Multi-organ Failure3.5%111
10
Neutropenia3.4%109
11
Sepsis3.3%105
12
Pyrexia3.3%104
13
Product Use In Unapproved Indication3.1%99
14
Neutropenia3.0%95
15
Mucosal Inflammation3.0%95

These are voluntary reports and do not establish that clofarabine caused these reactions.

Report severity

95.7%Serious3,044 reports
35.1%Hospitalizations1,117 reports
45.2%Fatal1,438 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clofarabine drug interactions

Other drugs that appear in adverse event reports alongside clofarabine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cytarabine30.1%959
2
Cyclophosphamide25.3%805
3
Etoposide20.6%655
4
Methotrexate10.9%348
5
Busulfan10.7%341
6
Fludarabine-phosphate10.7%340
7
Vincristine-sulfate7.8%247
8
Melphalan7.5%237
9
Dexamethasone6.4%202
10
Thiotepa6.2%197
11
Mycophenolate5.1%163
12
Idarubicin-hydrochloride5.1%161
13
Cyclosporine5.0%160
14
Prednisone4.2%134
15
Mercaptopurine4.1%129

Taken alongside

1
Acyclovir9.5%303
2
Fluconazole8.5%269
3
Ondansetron6.7%212
4
Tacrolimus6.6%209
5
Acetaminophen6.5%206
6
Cytarabine5.8%186
7
Levofloxacin5.6%178
8
Vancomycin5.6%177
9
Mycophenolate5.2%167
10
Sulfamethoxazole5.0%158
11
Allopurinol4.9%157
12
Cyclosporine4.9%157
13
Voriconazole4.9%155
14
Dexamethasone4.5%143
15
Hydrocortisone4.2%134

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clofarabine side effects

34.0% of clofarabine adverse event reports involve female patients and 46.0% involve male patients. The largest age group is adult at 44%. These figures reflect who reports side effects, not underlying risk.

Sex

Female34.0%
Male46.0%
Unknown20.0%

Age group

< 25.2%
2–1118.6%
12–1713.7%
18–6444.1%
65+18.4%

What is clofarabine used for

Conditions and purposes for which patients were taking clofarabine when the adverse event was reported.

5q Minus Syndrome5q-syndromeAccidental ExposureAcute Biphenotypic LeukaemiaAcute LeukaemiaAcute Leukaemia In RemissionAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Lymphocytic Leukaemia RefractoryAcute Megakaryocytic LeukaemiaAcute Monocytic LeukaemiaAcute Myeloid LeukaemiaAcute Myeloid Leukaemia RecurrentAcute Myeloid Leukaemia RefractoryAcute Myeloid Leukemia

Showing 15 of 174 indications

Clofarabine brand names and reporting trend

Clofarabine is sold under the brand name Clofarabine.

Brand names

Clofarabine3,026

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clofarabine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.