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Clocortolone Side Effects

The most commonly reported side effects of clocortolone include pruritus, rash, and erythema, based on 166 FDA adverse event reports from 2004 to 2025. 6.0% of reports found the drug to be ineffective.

Clocortolone side effects

Percentages show how often each reaction appears relative to total reports for clocortolone.

1
Pruritus7.8%13
2
Rash6.6%11
3
Erythema6.6%11
4
Drug Ineffective6.0%10
5
Nausea5.4%9
6
Psoriasis4.8%8
7
Dermatitis Atopic4.8%8
8
Eczema4.2%7
9
Skin Irritation4.2%7
10
Skin Burning Sensation3.6%6
11
Fatigue3.6%6
12
Swelling Face3.6%6
13
Sleep Disorder3.6%6
14
Paraesthesia3.0%5
15
Dry Skin3.0%5

These are voluntary reports and do not establish that clocortolone caused these reactions.

Report severity

40.4%Serious67 reports
16.3%Hospitalizations27 reports
5.4%Fatal9 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clocortolone drug interactions

Other drugs that appear in adverse event reports alongside clocortolone. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab15.1%25
2
Apremilast9.6%16
3
Adalimumab4.8%8
4
Sodium-oxybate4.2%7
5
Etanercept3.6%6
6
Isotretinoin3.0%5
7
Sildenafil-citrate2.4%4
8
Minocycline-hydrochloride1.8%3
9
Dexamethasone1.8%3
10
Triamcinolone1.8%3
11
Fluorouracil1.8%3
12
Ustekinumab1.8%3
13
Omeprazole1.8%3
14
Irinotecan-hydrochloride1.2%2
15
Panitumumab1.2%2

Taken alongside

1
Ergocalciferol12.7%21
2
Prednisone12.0%20
3
Acetaminophen11.4%19
4
Aspirin10.2%17
5
Triamcinolone10.2%17
6
Montelukast-sodium9.6%16
7
Fluticasone9.6%16
8
Cetirizine-hydrochloride9.0%15
9
Levothyroxine-sodium8.4%14
10
Amlodipine7.8%13
11
Ascorbic-acid7.8%13
12
Simvastatin7.8%13
13
Ibuprofen7.8%13
14
Omeprazole7.8%13
15
Furosemide7.2%12

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clocortolone side effects

56.0% of clocortolone adverse event reports involve female patients and 40.4% involve male patients. The largest age group is adult at 73%. These figures reflect who reports side effects, not underlying risk.

Sex

Female56.0%
Male40.4%
Unknown3.6%

Age group

< 20.0%
2–112.6%
12–177.9%
18–6472.8%
65+16.7%

What is clocortolone used for

Conditions and purposes for which patients were taking clocortolone when the adverse event was reported.

BlepharitisBody TineaContact DermatitisDermatitisDermatitis AtopicDrug Use For Unknown IndicationDermatitisDermatitis AtopicEczemaEyelid Skin DrynessEyelids PruritusEczemaErythemaFolliculitisHerpes Virus Infection

Showing 15 of 29 indications

Clocortolone brand names and reporting trend

Clocortolone is sold under the brand name Cloderm.

Brand names

Cloderm55

Quarterly reports (20042025)

2004201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clocortolone with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.