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Clobetasol Side Effects

The most commonly reported side effects of clobetasol include psoriasis, pruritus, and rash, based on 35,799 FDA adverse event reports from 2004 to 2025. 14.9% of reports found the drug to be ineffective.

Clobetasol side effects

Percentages show how often each reaction appears relative to total reports for clobetasol.

1
Drug Ineffective14.9%5,342
2
Psoriasis10.7%3,832
3
Pruritus7.1%2,540
4
Rash6.1%2,175
5
Off Label Use5.5%1,962
6
Diarrhoea4.8%1,730
7
Nausea4.6%1,655
8
Fatigue4.4%1,567
9
Headache4.3%1,556
10
Arthralgia4.3%1,542
11
Pain4.3%1,523
12
Product Use In Unapproved Indication4.1%1,464
13
Skin Exfoliation3.1%1,106
14
Product Dose Omission Issue3.0%1,070
15
Erythema2.9%1,041

These are voluntary reports and do not establish that clobetasol caused these reactions.

Report severity

44.2%Serious15,807 reports
17.4%Hospitalizations6,215 reports
3.5%Fatal1,241 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clobetasol drug interactions

Other drugs that appear in adverse event reports alongside clobetasol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Dupilumab13.9%4,980
2
Apremilast10.6%3,805
3
Adalimumab6.4%2,306
4
Secukinumab6.4%2,290
5
Triamcinolone5.2%1,853
6
Methotrexate4.8%1,725
7
Etanercept3.6%1,283
8
Prednisone2.6%915
9
Hydrocortisone2.2%771
10
Betamethasone2.0%710
11
Tacrolimus1.8%646
12
Sodium-oxybate1.7%609
13
Calcipotriene1.7%591
14
Cyclosporine1.6%572
15
Lenalidomide1.6%560

Taken alongside

1
Acetaminophen14.3%5,105
2
Ergocalciferol13.4%4,784
3
Triamcinolone12.0%4,290
4
Levothyroxine-sodium11.6%4,143
5
Albuterol11.5%4,111
6
Aspirin10.8%3,855
7
Omeprazole10.3%3,691
8
Fluticasone10.1%3,613
9
Prednisone9.8%3,503
10
Atorvastatin-calcium9.3%3,344
11
Gabapentin8.5%3,054
12
Amlodipine8.0%2,865
13
Metformin7.2%2,567
14
Lisinopril6.8%2,447
15
Metoprolol6.8%2,439

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clobetasol side effects

57.8% of clobetasol adverse event reports involve female patients and 34.4% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female57.8%
Male34.4%
Unknown7.8%

Age group

< 20.5%
2–111.5%
12–172.0%
18–6461.8%
65+34.3%

What is clobetasol used for

Conditions and purposes for which patients were taking clobetasol when the adverse event was reported.

Abdominal DiscomfortAbscessAbscess LimbAcarodermatitisAccidental Exposure To ProductAccidental Exposure To Product By ChildAcneAcrodermatitisActinic KeratosisAcute Febrile Neutrophilic DermatosisAcute Generalised Exanthematous PustulosisAcute Graft Versus Host DiseaseAcute Graft Versus Host Disease In SkinAcute PsychosisAdrenocortical Steroid Therapy

Showing 15 of 758 indications

Clobetasol brand names and reporting trend

Clobetasol is sold under the brand name Temovate.

Brand names

Temovate35,671

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clobetasol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.