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Clobazam Side Effects

The most commonly reported side effects of clobazam include seizure, off label use, and somnolence, based on 23,545 FDA adverse event reports from 2004 to 2025. 12.7% of reports found the drug to be ineffective.

Clobazam side effects

Percentages show how often each reaction appears relative to total reports for clobazam.

1
Seizure19.7%4,642
2
Drug Ineffective12.7%2,983
3
Off Label Use8.7%2,037
4
Somnolence7.4%1,746
5
Fatigue4.5%1,069
6
Drug Interaction4.5%1,060
7
Epilepsy3.3%768
8
Condition Aggravated3.2%757
9
Product Use In Unapproved Indication3.0%701
10
Status Epilepticus2.8%654
11
Pneumonia2.8%650
12
Fall2.6%605
13
Aggression2.6%604
14
Decreased Appetite2.6%603
15
Generalised Tonic-clonic Seizure2.5%597

These are voluntary reports and do not establish that clobazam caused these reactions.

Report severity

78.5%Serious18,485 reports
34.0%Hospitalizations8,012 reports
6.6%Fatal1,550 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clobazam drug interactions

Other drugs that appear in adverse event reports alongside clobazam. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Levetiracetam22.8%5,375
2
Cannabidiol14.6%3,426
3
Lamotrigine11.5%2,714
4
Lacosamide10.0%2,351
5
Topiramate9.4%2,224
6
Valproic-acid8.8%2,073
7
Carbamazepine7.3%1,730
8
Phenytoin6.9%1,630
9
Vigabatrin6.7%1,573
10
Valproate-sodium5.6%1,326
11
Phenobarbital-sodium5.5%1,293
12
Stiripentol4.2%981
13
Zonisamide4.2%981
14
Oxcarbazepine4.0%947
15
Clonazepam4.0%941

Taken alongside

1
Levetiracetam16.8%3,959
2
Lamotrigine9.9%2,326
3
Topiramate8.3%1,966
4
Lacosamide8.1%1,898
5
Clonazepam6.8%1,609
6
Diazepam6.5%1,530
7
Divalproex-sodium5.4%1,271
8
Zonisamide5.3%1,244
9
Valproic-acid5.2%1,230
10
Phenobarbital-sodium4.2%989
11
Acetaminophen4.2%989
12
Oxcarbazepine4.1%963
13
Lorazepam4.0%953
14
Phenytoin4.0%949
15
Carbamazepine4.0%936

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clobazam side effects

39.6% of clobazam adverse event reports involve female patients and 37.1% involve male patients. The largest age group is adult at 47%. These figures reflect who reports side effects, not underlying risk.

Sex

Female39.6%
Male37.1%
Unknown23.3%

Age group

< 28.5%
2–1126.1%
12–1710.9%
18–6447.4%
65+7.1%

What is clobazam used for

Conditions and purposes for which patients were taking clobazam when the adverse event was reported.

Abnormal BehaviourAccidental OverdoseAcquired Epileptic AphasiaAggressionAicardi^s SyndromeAlexander DiseaseAltered State Of ConsciousnessAmnesiaAnaesthesiaAngelman^s SyndromeAnticoagulant TherapyAnticonvulsant Drug LevelAntidepressant TherapyAnxietyAnxiety Disorder

Showing 15 of 436 indications

Clobazam brand names and reporting trend

Clobazam is sold under the brand name Sympazan.

Brand names

Sympazan19,676

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clobazam with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.