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Clioquinol Side Effects

The most commonly reported side effects of clioquinol include insomnia, oedema, and pain in extremity, based on 302 FDA adverse event reports from 2005 to 2025.

Clioquinol side effects

Percentages show how often each reaction appears relative to total reports for clioquinol.

1
Insomnia42.7%129
2
Oedema41.1%124
3
Pain In Extremity40.7%123
4
Joint Swelling39.4%119
5
Condition Aggravated35.8%108
6
Pemphigus35.4%107
7
Injury34.8%105
8
Contusion33.8%102
9
Pyrexia33.8%102
10
C-reactive Protein Abnormal33.4%101
11
Psoriatic Arthropathy33.4%101
12
Sleep Disorder33.4%101
13
Discomfort32.1%97
14
Type 2 Diabetes Mellitus32.1%97
15
Diarrhoea30.8%93

These are voluntary reports and do not establish that clioquinol caused these reactions.

Report severity

99.7%Serious301 reports
63.6%Hospitalizations192 reports
47.7%Fatal144 reports

Seriousness is determined by the reporter, not by OpenClaim.

Clioquinol drug interactions

Other drugs that appear in adverse event reports alongside clioquinol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Abatacept63.6%192
2
Methotrexate60.9%184
3
Folic-acid58.3%176
4
Diclofenac58.3%176
5
Leflunomide57.6%174
6
Etanercept57.6%174
7
Tocilizumab57.6%174
8
Oxycodone57.3%173
9
Hydrocortisone57.0%172
10
Certolizumab-pegol56.6%171
11
Adalimumab56.6%171
12
Alendronate-sodium56.3%170
13
Desoximetasone55.6%168
14
Hydroxychloroquine-sulfate55.0%166
15
Secukinumab54.3%164

Taken alongside

1
Acetaminophen42.1%127
2
Lorazepam42.1%127
3
Pantoprazole-sodium40.1%121
4
Ibuprofen33.8%102
5
Ergocalciferol32.5%98
6
Quetiapine-fumarate30.8%93
7
Lisinopril29.5%89
8
Eszopiclone29.1%88
9
Sulfasalazine27.2%82
10
Desogestrel27.2%82
11
Fish26.5%80
12
Cetirizine-hydrochloride26.2%79
13
Ethinyl-estradiol26.2%79
14
Lansoprazole25.8%78
15
Ascorbic-acid23.2%70

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports clioquinol side effects

66.6% of clioquinol adverse event reports involve female patients and 15.6% involve male patients. The largest age group is adult at 86%. These figures reflect who reports side effects, not underlying risk.

Sex

Female66.6%
Male15.6%
Unknown17.9%

Age group

< 20.0%
2–110.0%
12–170.0%
18–6486.2%
65+13.8%

What is clioquinol used for

Conditions and purposes for which patients were taking clioquinol when the adverse event was reported.

BlisterCrohn^s DiseaseDermatitis AtopicEar PainEczemaHerpes ZosterProduct Used For Unknown IndicationPsoriasisProduct Used For Unknown IndicationRheumatoid ArthritisSkin Lesion

Clioquinol brand names and reporting trend

Clioquinol is sold under the brand name Nystaform.

Brand names

Nystaform327

Quarterly reports (20052025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking clioquinol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.