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Cisplatin Side Effects

The most commonly reported side effects of cisplatin include off label use, disease progression, and neutropenia, based on 79,246 FDA adverse event reports from 2004 to 2025. 3.9% of reports found the drug to be ineffective.

#1 Reported: Off Label UseAll side effects ↓Top Co-Medication: EtoposideDrug interactions ↓60% of Reports Are AdultDemographics ↓

Cisplatin side effects

Percentages show how often each reaction appears relative to total reports for cisplatin.

1
Off Label Use7.3%5,751
2
Disease Progression5.5%4,331
3
Neutropenia4.9%3,864
4
Nausea4.8%3,803
5
Febrile Neutropenia4.6%3,651
6
Anaemia4.1%3,224
7
Thrombocytopenia3.9%3,130
8
Drug Ineffective3.9%3,120
9
Vomiting3.8%3,035
10
Malignant Neoplasm Progression3.6%2,818
11
Diarrhoea3.4%2,712
12
Pyrexia3.0%2,414
13
Myelosuppression3.0%2,339
14
Death2.9%2,332
15
Acute Kidney Injury2.6%2,026

These are voluntary reports and do not establish that cisplatin caused these reactions.

Report severity

96.9%Serious76,756 reports
42.0%Hospitalizations33,312 reports
19.2%Fatal15,178 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cisplatin drug interactions

Other drugs that appear in adverse event reports alongside cisplatin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Etoposide20.5%16,215
2
Gemcitabine16.6%13,131
3
Doxorubicin-hydrochloride15.4%12,242
4
Cyclophosphamide12.6%9,953
5
Dexamethasone11.7%9,253
6
Vincristine-sulfate9.9%7,833
7
Fluorouracil9.3%7,390
8
Carboplatin8.4%6,670
9
Paclitaxel8.3%6,562
10
Pemetrexed8.2%6,485
11
Rituximab8.1%6,421
12
Docetaxel7.1%5,658
13
Cytarabine7.1%5,595
14
Ifosfamide5.7%4,514
15
Bevacizumab5.6%4,402

Taken alongside

1
Dexamethasone8.0%6,329
2
Ondansetron4.5%3,530
3
Etoposide3.9%3,106
4
Gemcitabine3.6%2,852
5
Acetaminophen3.4%2,665
6
Doxorubicin-hydrochloride2.7%2,166
7
Aprepitant2.6%2,060
8
Cyclophosphamide2.4%1,907
9
Folic-acid2.3%1,862
10
Pantoprazole-sodium2.2%1,757
11
Omeprazole2.1%1,676
12
Metoclopramide-hydrochloride2.1%1,668
13
Carboplatin2.1%1,647
14
Fluorouracil2.1%1,643
15
Furosemide2.0%1,555

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cisplatin side effects

33.1% of cisplatin adverse event reports involve female patients and 50.0% involve male patients. The largest age group is adult at 60%. These figures reflect who reports side effects, not underlying risk.

Sex

Female33.1%
Male50.0%
Unknown17.0%

Age group

< 21.4%
2–114.0%
12–172.5%
18–6460.3%
65+31.7%

What is cisplatin used for

Conditions and purposes for which patients were taking cisplatin when the adverse event was reported.

Abdominal LymphadenopathyAccidental Exposure To ProductAcinar Cell Carcinoma Of PancreasAcquired Gene MutationAcral Lentiginous Melanoma Stage UnspecifiedActh-producing Pituitary TumourAcute Lymphocytic LeukaemiaAcute Lymphocytic Leukaemia RecurrentAcute Myeloid LeukaemiaAdenocarcinomaAdenocarcinoma GastricAdenocarcinoma LungAdenocarcinoma MetastaticAdenocarcinoma Of ColonAdenocarcinoma Of The Cervix

Showing 15 of 2,092 indications

Cisplatin brand names and reporting trend

Cisplatin is sold under the brand name Cisplatin.

Brand names

Cisplatin92,352

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cisplatin with another medication?

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