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Ciprofloxacin Side Effects

The most commonly reported side effects of ciprofloxacin include drug hypersensitivity, fatigue, and pain, based on 111,734 FDA adverse event reports from 2004 to 2025. 4.5% of reports found the drug to be ineffective.

Ciprofloxacin side effects

Percentages show how often each reaction appears relative to total reports for ciprofloxacin.

1
Drug Hypersensitivity5.5%6,167
2
Fatigue5.5%6,154
3
Pain5.2%5,814
4
Diarrhoea5.0%5,618
5
Arthralgia4.9%5,527
6
Nausea4.9%5,465
7
Drug Ineffective4.5%5,061
8
Acute Kidney Injury4.5%5,009
9
Off Label Use4.3%4,838
10
Chronic Kidney Disease4.2%4,734
11
Dyspnoea3.9%4,376
12
Vomiting3.6%4,048
13
Headache3.6%4,045
14
Anxiety3.5%3,934
15
Pyrexia3.4%3,814

These are voluntary reports and do not establish that ciprofloxacin caused these reactions.

Report severity

83.3%Serious93,078 reports
39.1%Hospitalizations43,651 reports
10.2%Fatal11,408 reports

Seriousness is determined by the reporter, not by OpenClaim.

Ciprofloxacin drug interactions

Other drugs that appear in adverse event reports alongside ciprofloxacin. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole4.5%5,059
2
Esomeprazole4.0%4,507
3
Metronidazole3.8%4,252
4
Pantoprazole-sodium3.8%4,223
5
Levofloxacin3.2%3,563
6
Prednisone3.1%3,476
7
Lansoprazole3.1%3,454
8
Moxifloxacin-hydrochloride2.6%2,937
9
Lenalidomide2.5%2,772
10
Dexamethasone2.4%2,722
11
Amoxicillin2.4%2,651
12
Vancomycin2.4%2,631
13
Adalimumab2.3%2,519
14
Infliximab2.2%2,453
15
Rituximab2.1%2,337

Taken alongside

1
Acetaminophen14.6%16,317
2
Aspirin9.0%10,090
3
Furosemide8.8%9,861
4
Prednisone8.1%9,074
5
Omeprazole7.9%8,780
6
Ergocalciferol7.3%8,208
7
Albuterol7.3%8,200
8
Metronidazole7.3%8,163
9
Ondansetron6.7%7,524
10
Levothyroxine-sodium6.7%7,503
11
Amoxicillin6.5%7,219
12
Pantoprazole-sodium6.3%7,032
13
Amlodipine6.2%6,965
14
Atorvastatin-calcium6.2%6,938
15
Gabapentin5.7%6,356

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports ciprofloxacin side effects

52.9% of ciprofloxacin adverse event reports involve female patients and 38.5% involve male patients. The largest age group is adult at 57%. These figures reflect who reports side effects, not underlying risk.

Sex

Female52.9%
Male38.5%
Unknown8.5%

Age group

< 20.7%
2–111.8%
12–171.9%
18–6456.9%
65+38.9%

What is ciprofloxacin used for

Conditions and purposes for which patients were taking ciprofloxacin when the adverse event was reported.

Abdominal AbscessAbdominal DiscomfortAbdominal DistensionAbdominal InfectionAbdominal LymphadenopathyAbdominal PainAbdominal Pain LowerAbdominal Pain UpperAbdominal SepsisAbdominal Wall WoundAbdominoplastyAbnormal FaecesAbortion CompleteAbrasion NosAbscess

Showing 15 of 2,777 indications

Ciprofloxacin brand names and reporting trend

Ciprofloxacin is sold under brand names including Cipro, Ciloxan.

Brand names

Cipro98,677
Ciloxan91

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking ciprofloxacin with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.