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Cinacalcet Side Effects

The most commonly reported side effects of cinacalcet include drug dose omission, hospitalisation, and laboratory test abnormal, based on 49,649 FDA adverse event reports from 2004 to 2025. 1.5% of reports found the drug to be ineffective.

Cinacalcet side effects

Percentages show how often each reaction appears relative to total reports for cinacalcet.

1
Drug Dose Omission17.6%8,740
2
Hospitalisation14.0%6,953
3
Laboratory Test Abnormal8.5%4,222
4
Off Label Use5.6%2,760
5
Nausea4.4%2,205
6
Intentional Product Misuse4.2%2,087
7
Death4.1%2,020
8
Malaise3.1%1,548
9
Vomiting3.0%1,508
10
Adverse Drug Reaction2.9%1,462
11
Diarrhoea2.3%1,118
12
Decreased Appetite1.7%829
13
Abdominal Discomfort1.5%767
14
Drug Ineffective1.5%720
15
Muscle Spasms1.2%582

These are voluntary reports and do not establish that cinacalcet caused these reactions.

Report severity

40.0%Serious19,862 reports
25.4%Hospitalizations12,618 reports
6.3%Fatal3,106 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cinacalcet drug interactions

Other drugs that appear in adverse event reports alongside cinacalcet. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Omeprazole0.9%461
2
Esomeprazole0.9%448
3
Patiromer-sorbitex-calcium0.7%371
4
Pantoprazole-sodium0.7%362
5
Dextrose0.7%354
6
Lansoprazole0.7%328
7
Tacrolimus0.6%321
8
Etelcalcetide0.6%318
9
Sodium-chloride0.6%289
10
Denosumab0.5%267
11
Mycophenolate0.5%245
12
Magnesium-chloride0.5%241
13
Calcium-chloride0.5%234
14
Sodium-lactate0.5%234
15
Sevelamer0.4%196

Taken alongside

1
Sevelamer4.9%2,446
2
Aspirin3.7%1,823
3
Amlodipine3.4%1,670
4
Metoprolol2.9%1,421
5
Atorvastatin-calcium2.9%1,417
6
Acetaminophen2.8%1,374
7
Furosemide2.6%1,280
8
Insulin2.5%1,218
9
Ergocalciferol2.4%1,170
10
Carvedilol2.1%1,057
11
Calcitriol2.0%982
12
Omeprazole1.9%957
13
Levothyroxine-sodium1.9%934
14
Prednisone1.8%911
15
Gabapentin1.8%907

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cinacalcet side effects

47.5% of cinacalcet adverse event reports involve female patients and 41.0% involve male patients. The largest age group is adult at 62%. These figures reflect who reports side effects, not underlying risk.

Sex

Female47.5%
Male41.0%
Unknown11.4%

Age group

< 20.3%
2–110.3%
12–170.2%
18–6462.2%
65+36.9%

What is cinacalcet used for

Conditions and purposes for which patients were taking cinacalcet when the adverse event was reported.

Abscess IntestinalAcromegalyAcute Kidney InjuryAddison's DiseaseAdjusted CalciumAdjusted Calcium IncreasedAnaemiaAnaemia Of Chronic DiseaseAngina PectorisAnxietyArthropathyAstheniaAtrial FibrillationAbnormal BehaviourAcquired Hypocalciuric Hypercalcaemia

Showing 15 of 305 indications

Cinacalcet brand names and reporting trend

Cinacalcet is sold under the brand name Cinacalcet Hydrochloride.

Brand names

Cinacalcet Hydrochloride112

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cinacalcet with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.