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Cilostazol Side Effects

The most commonly reported side effects of cilostazol include diarrhoea, off label use, and death, based on 9,120 FDA adverse event reports from 2004 to 2025. 2.5% of reports found the drug to be ineffective.

Cilostazol side effects

Percentages show how often each reaction appears relative to total reports for cilostazol.

1
Diarrhoea3.5%318
2
Off Label Use2.6%240
3
Death2.6%239
4
Drug Ineffective2.5%227
5
Pneumonia2.5%224
6
Nausea2.4%215
7
Dyspnoea2.3%210
8
Fall2.3%208
9
Fatigue2.1%193
10
Acute Kidney Injury2.0%184
11
Anaemia2.0%180
12
Asthenia2.0%178
13
Vomiting1.9%175
14
Pain In Extremity1.8%166
15
Dizziness1.8%164

These are voluntary reports and do not establish that cilostazol caused these reactions.

Report severity

82.6%Serious7,536 reports
47.9%Hospitalizations4,367 reports
15.5%Fatal1,418 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cilostazol drug interactions

Other drugs that appear in adverse event reports alongside cilostazol. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Aspirin6.7%608
2
Clopidogrel-bisulfate3.0%270
3
Rivaroxaban2.5%227
4
Gemfibrozil2.4%215
5
Omeprazole2.1%189
6
Atorvastatin-calcium2.1%187
7
Valsartan1.9%173
8
Esomeprazole1.9%170
9
Insulin1.8%164
10
Lenalidomide1.8%162
11
Adalimumab1.8%160
12
Pregabalin1.7%154
13
Warfarin1.4%129
14
Amlodipine1.4%126
15
Lansoprazole1.3%122

Taken alongside

1
Aspirin28.8%2,630
2
Amlodipine15.5%1,414
3
Atorvastatin-calcium15.3%1,399
4
Furosemide14.3%1,307
5
Metoprolol12.4%1,129
6
Insulin10.7%974
7
Acetaminophen9.8%890
8
Simvastatin9.7%887
9
Metformin9.7%886
10
Omeprazole8.9%813
11
Lisinopril8.5%774
12
Clopidogrel-bisulfate8.3%761
13
Gabapentin8.2%750
14
Levothyroxine-sodium7.4%674
15
Rosuvastatin7.1%644

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cilostazol side effects

38.0% of cilostazol adverse event reports involve female patients and 55.4% involve male patients. The largest age group is elderly at 72%. These figures reflect who reports side effects, not underlying risk.

Sex

Female38.0%
Male55.4%
Unknown6.6%

Age group

< 20.1%
2–110.1%
12–17<0.1%
18–6427.3%
65+72.3%

What is cilostazol used for

Conditions and purposes for which patients were taking cilostazol when the adverse event was reported.

Abdominal DiscomfortAcute Coronary SyndromeAcute Myocardial InfarctionAdverse EventAmputationAnalgesic EffectAnalgesic TherapyAngina PectorisAngina UnstableAngiopathyAngioplastyAnkle SwellingAnticoagulant TherapyAntiplatelet TherapyAortic Arteriosclerosis

Showing 15 of 426 indications

Cilostazol brand names and reporting trend

Cilostazol is sold under the brand name Pletal.

Brand names

Pletal6,606

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cilostazol with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.