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Chymopapain Side Effects

The most commonly reported side effects of chymopapain include fatigue, nausea, and covid-19, based on 156 FDA adverse event reports from 2004 to 2025. 6.4% of reports found the drug to be ineffective.

Chymopapain side effects

Percentages show how often each reaction appears relative to total reports for chymopapain.

1
Fatigue9.0%14
2
Drug Ineffective6.4%10
3
Nausea5.8%9
4
Covid-195.1%8
5
Arthralgia4.5%7
6
Fall4.5%7
7
Vomiting4.5%7
8
Off Label Use4.5%7
9
Pain3.8%6
10
Headache3.8%6
11
Nausea3.8%6
12
Dizziness3.8%6
13
Disease Recurrence3.8%6
14
Malaise3.2%5
15
Erythema3.2%5

These are voluntary reports and do not establish that chymopapain caused these reactions.

Report severity

56.4%Serious88 reports
20.5%Hospitalizations32 reports
6.4%Fatal10 reports

Seriousness is determined by the reporter, not by OpenClaim.

Chymopapain drug interactions

Other drugs that appear in adverse event reports alongside chymopapain. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Adalimumab9.6%15
2
Nirmatrelvir7.1%11
3
Ritonavir7.1%11
4
Sodium-oxybate6.4%10
5
Interferon4.5%7
6
Naproxen3.2%5
7
Quetiapine-fumarate3.2%5
8
Omeprazole2.6%4
9
Albuterol2.6%4
10
Polyethylene-glycol-33502.6%4
11
Esomeprazole2.6%4
12
Lidocaine1.9%3
13
Digoxin1.9%3
14
Budesonide1.9%3
15
Pantoprazole-sodium1.9%3

Taken alongside

1
Ergocalciferol14.7%23
2
Acetaminophen13.5%21
3
Aspirin12.8%20
4
Prednisone10.3%16
5
Hydrocodone10.3%16
6
Gabapentin10.3%16
7
Omeprazole9.6%15
8
Fluticasone9.0%14
9
Metoprolol8.3%13
10
Tramadol-hydrochloride8.3%13
11
Levothyroxine-sodium7.7%12
12
Ibuprofen7.7%12
13
Alprazolam7.7%12
14
Biotin7.7%12
15
Cyanocobalamin7.7%12

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports chymopapain side effects

67.3% of chymopapain adverse event reports involve female patients and 26.3% involve male patients. The largest age group is adult at 61%. These figures reflect who reports side effects, not underlying risk.

Sex

Female67.3%
Male26.3%
Unknown6.4%

Age group

< 20.0%
2–110.9%
12–170.0%
18–6460.9%
65+38.2%

What is chymopapain used for

Conditions and purposes for which patients were taking chymopapain when the adverse event was reported.

Allergic SinusitisBack PainBone PainBezoarCalciphylaxisDrug Use For Unknown IndicationFibromyalgiaInfected NeoplasmIntervertebral Disc ProtrusionMultiple AllergiesNeck PainPainProduct Used For Unknown IndicationProphylaxisProduct Used For Unknown Indication

Showing 15 of 16 indications

Chymopapain brand names and reporting trend

Chymopapain is sold under the brand name Chymodiactin.

Brand names

Chymodiactin160

Quarterly reports (20042025)

2004201020152025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking chymopapain with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.