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Choline Side Effects

The most commonly reported side effects of choline include flushing, myalgia, and pruritus, based on 5,002 FDA adverse event reports from 2004 to 2025. 1.8% of reports found the drug to be ineffective.

Choline side effects

Percentages show how often each reaction appears relative to total reports for choline.

1
Flushing6.8%340
2
Myalgia4.3%213
3
Pruritus3.9%194
4
Nausea3.2%161
5
Rash2.7%137
6
Headache2.7%135
7
Chronic Kidney Disease2.7%134
8
Blood Triglycerides Increased2.6%130
9
Blood Creatinine Increased2.6%128
10
Fatigue2.2%112
11
Nausea2.2%108
12
Renal Failure2.1%107
13
Feeling Hot2.1%106
14
Diarrhoea2.1%106
15
Fatigue1.9%97

These are voluntary reports and do not establish that choline caused these reactions.

Report severity

35.2%Serious1,759 reports
16.3%Hospitalizations813 reports
2.9%Fatal144 reports

Seriousness is determined by the reporter, not by OpenClaim.

Choline drug interactions

Other drugs that appear in adverse event reports alongside choline. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Niacin11.5%575
2
Adalimumab4.5%227
3
Esomeprazole3.2%159
4
Rosuvastatin2.9%144
5
Omeprazole2.4%122
6
Atorvastatin-calcium1.7%86
7
Sodium-oxybate1.6%82
8
Pantoprazole-sodium1.5%74
9
Fenofibrate1.4%69
10
Lansoprazole1.4%68
11
Dabigatran-etexilate-mesylate1.3%67
12
Exenatide-synthetic1.3%64
13
Lenalidomide1.2%61
14
Simvastatin1.1%56
15
Omega0.9%46

Taken alongside

1
Aspirin24.1%1,206
2
Metformin15.9%796
3
Metoprolol12.7%637
4
Lisinopril12.4%621
5
Rosuvastatin12.2%608
6
Levothyroxine-sodium12.2%608
7
Ergocalciferol12.1%606
8
Simvastatin11.2%559
9
Atorvastatin-calcium10.5%525
10
Insulin10.2%508
11
Amlodipine10.1%505
12
Acetaminophen10.0%499
13
Hydrochlorothiazide9.0%452
14
Furosemide8.7%434
15
Omeprazole7.9%393

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports choline side effects

42.2% of choline adverse event reports involve female patients and 46.5% involve male patients. The largest age group is adult at 63%. These figures reflect who reports side effects, not underlying risk.

Sex

Female42.2%
Male46.5%
Unknown11.3%

Age group

< 2<0.1%
2–11<0.1%
12–17<0.1%
18–6463.4%
65+36.4%

What is choline used for

Conditions and purposes for which patients were taking choline when the adverse event was reported.

Analgesic TherapyAnxietyApolipoprotein B IncreasedBlood CholesterolBlood Cholesterol AbnormalBlood Cholesterol IncreasedBlood Fibrinogen IncreasedBlood Glucose AbnormalBlood Glucose DecreasedBlood PressureBlood Pressure AbnormalBlood TriglyceridesBlood Triglycerides AbnormalBlood Triglycerides DecreasedBlood Triglycerides Increased

Showing 15 of 76 indications

Choline brand names and reporting trend

Choline is sold under the brand name Trilipix.

Brand names

Trilipix229

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking choline with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.