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Cholic Side Effects

The most commonly reported side effects of cholic include diarrhoea, death, and vomiting, based on 638 FDA adverse event reports from 2004 to 2025. 2.2% of reports found the drug to be ineffective.

Cholic side effects

Percentages show how often each reaction appears relative to total reports for cholic.

1
Diarrhoea9.6%61
2
Death6.7%43
3
Vomiting5.0%32
4
Pyrexia4.1%26
5
Constipation3.8%24
6
Aspartate Aminotransferase Increased3.1%20
7
Seizure3.1%20
8
Alanine Aminotransferase Increased3.0%19
9
Disease Progression2.7%17
10
Decreased Appetite2.7%17
11
Abdominal Pain2.5%16
12
Stomatitis2.4%15
13
Drug Ineffective2.2%14
14
Cough2.2%14
15
Off Label Use2.2%14

These are voluntary reports and do not establish that cholic caused these reactions.

Report severity

65.0%Serious415 reports
31.2%Hospitalizations199 reports
20.2%Fatal129 reports

Seriousness is determined by the reporter, not by OpenClaim.

Cholic drug interactions

Other drugs that appear in adverse event reports alongside cholic. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Cyclosporine3.8%24
2
Busulfan3.1%20
3
Mycophenolate3.0%19
4
Tacrolimus3.0%19
5
Prednisolone2.7%17
6
Methotrexate2.7%17
7
Cyclophosphamide2.4%15
8
Fludarabine-phosphate1.9%12
9
Defibrotide-sodium1.7%11
10
Adalimumab1.6%10
11
Blinatumomab1.6%10
12
Prednisone1.4%9
13
Rituximab1.4%9
14
Amoxicillin1.1%7
15
Paclitaxel1.1%7

Taken alongside

1
Furosemide7.4%47
2
Omeprazole6.3%40
3
Levetiracetam5.6%36
4
Acetaminophen4.4%28
5
Ergocalciferol4.2%27
6
Amlodipine4.1%26
7
Hydrocortisone4.1%26
8
Pantoprazole-sodium4.1%26
9
Ranitidine3.9%25
10
Aspirin3.8%24
11
Spironolactone3.3%21
12
Prednisolone3.1%20
13
Albuterol3.0%19
14
Ferrous-sulfate3.0%19
15
Amoxicillin3.0%19

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports cholic side effects

48.9% of cholic adverse event reports involve female patients and 44.4% involve male patients. The largest age group is adult at 30%. These figures reflect who reports side effects, not underlying risk.

Sex

Female48.9%
Male44.4%
Unknown6.7%

Age group

< 229.0%
2–1119.8%
12–175.8%
18–6430.0%
65+15.3%

What is cholic used for

Conditions and purposes for which patients were taking cholic when the adverse event was reported.

Adrenogenital SyndromeAdrenoleukodystrophyAlcoholic Liver DiseaseAntiphospholipid SyndromeAutoimmune HepatitisBile Duct ObstructionBiliary Cirrhosis PrimaryBiliary Tract DisorderBlood Bilirubin IncreasedBlood Lactate Dehydrogenase IncreasedBile Acid Synthesis DisorderBiliary ObstructionBiliary Tract DisorderCerebrohepatorenal SyndromeCholangitis

Showing 15 of 94 indications

Cholic brand names and reporting trend

Cholic is sold under the brand name Cholbam.

Brand names

Cholbam457

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking cholic with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.