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Chlorpromazine Side Effects

The most commonly reported side effects of chlorpromazine include off label use, toxicity to various agents, and diabetes mellitus, based on 9,561 FDA adverse event reports from 2004 to 2025. 5.9% of reports found the drug to be ineffective.

#1 Reported: Off Label UseAll side effects ↓Top Co-Medication: Quetiapine-fumarateDrug interactions ↓75% of Reports Are AdultDemographics ↓

Chlorpromazine side effects

Percentages show how often each reaction appears relative to total reports for chlorpromazine.

1
Drug Ineffective5.9%567
2
Off Label Use5.2%496
3
Toxicity To Various Agents4.5%434
4
Diabetes Mellitus4.4%417
5
Type 2 Diabetes Mellitus4.0%379
6
Overdose3.5%332
7
Nausea3.1%301
8
Drug Interaction2.9%278
9
Fatigue2.9%276
10
Neutropenia2.7%261
11
Psychotic Disorder2.5%240
12
Seizure2.5%239
13
Neuroleptic Malignant Syndrome2.4%234
14
Diarrhoea2.4%231
15
Vomiting2.4%225

These are voluntary reports and do not establish that chlorpromazine caused these reactions.

Report severity

89.7%Serious8,579 reports
44.6%Hospitalizations4,265 reports
17.0%Fatal1,629 reports

Seriousness is determined by the reporter, not by OpenClaim.

Chlorpromazine drug interactions

Other drugs that appear in adverse event reports alongside chlorpromazine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Quetiapine-fumarate16.7%1,597
2
Olanzapine14.0%1,336
3
Risperidone11.7%1,116
4
Haloperidol11.1%1,059
5
Clozapine10.1%967
6
Aripiprazole7.6%727
7
Lorazepam5.3%502
8
Lithium4.8%458
9
Diazepam4.2%400
10
Valproic-acid3.8%360
11
Clonazepam3.3%317
12
Gabapentin3.1%295
13
Carbamazepine3.0%283
14
Sertraline-hydrochloride2.8%271
15
Venlafaxine2.6%252

Taken alongside

1
Acetaminophen10.3%981
2
Lorazepam9.2%875
3
Haloperidol8.7%831
4
Risperidone8.2%780
5
Olanzapine7.2%684
6
Clonazepam6.1%588
7
Omeprazole5.9%566
8
Aripiprazole5.6%537
9
Diazepam5.5%530
10
Aspirin5.4%520
11
Gabapentin5.0%478
12
Levothyroxine-sodium5.0%476
13
Metformin4.9%464
14
Lithium4.8%459
15
Ondansetron4.8%456

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports chlorpromazine side effects

40.5% of chlorpromazine adverse event reports involve female patients and 50.5% involve male patients. The largest age group is adult at 75%. These figures reflect who reports side effects, not underlying risk.

Sex

Female40.5%
Male50.5%
Unknown9.0%

Age group

< 22.0%
2–112.2%
12–174.6%
18–6474.8%
65+16.5%

What is chlorpromazine used for

Conditions and purposes for which patients were taking chlorpromazine when the adverse event was reported.

Abdominal DiscomfortAbdominal DistensionAbdominal PainAbnormal BehaviourAccidental ExposureAcute PsychosisAdjustment DisorderAdverse EventAffective DisorderAggressionAgitated DepressionAgitationAgoraphobiaAlcoholic PsychosisAltered State Of Consciousness

Showing 15 of 376 indications

Chlorpromazine brand names and reporting trend

Chlorpromazine is sold under brand names including Thorazine, Chlorpromazine Hydrochloride Intensol.

Brand names

Thorazine9,849
Chlorpromazine Hydrochloride Intensol46

Quarterly reports (2004–2025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking chlorpromazine with another medication?

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