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Chlorpheniramine Side Effects

The most commonly reported side effects of chlorpheniramine include anosmia, ageusia, and nausea, based on 19,070 FDA adverse event reports from 2004 to 2025. 3.4% of reports found the drug to be ineffective.

Chlorpheniramine side effects

Percentages show how often each reaction appears relative to total reports for chlorpheniramine.

1
Anosmia8.9%1,693
2
Ageusia7.0%1,329
3
Nausea4.9%933
4
Diarrhoea4.6%875
5
Dependence4.4%833
6
Off Label Use4.1%786
7
Dyspnoea4.0%769
8
Fatigue3.8%721
9
Overdose3.7%702
10
Pyrexia3.6%685
11
Vomiting3.5%661
12
Drug Ineffective3.4%655
13
Death2.7%514
14
Headache2.6%496
15
Pneumonia2.4%463

These are voluntary reports and do not establish that chlorpheniramine caused these reactions.

Report severity

72.5%Serious13,832 reports
32.4%Hospitalizations6,177 reports
13.6%Fatal2,591 reports

Seriousness is determined by the reporter, not by OpenClaim.

Chlorpheniramine drug interactions

Other drugs that appear in adverse event reports alongside chlorpheniramine. Drugs flagged as a suspected cause appear in the first column. Drugs taken at the same time but not suspected appear in the second.

Also suspected

1
Phenylpropanolamine21.9%4,185
2
Acetaminophen8.4%1,611
3
Hydrocodone6.4%1,222
4
Oxycodone5.2%990
5
Paclitaxel5.1%974
6
Ibuprofen4.8%918
7
Trastuzumab4.2%799
8
Tramadol-hydrochloride3.8%717
9
Carboplatin3.2%616
10
Rituximab3.2%604
11
Docetaxel3.1%600
12
Pertuzumab3.1%589
13
Morphine-sulfate3.1%586
14
Pseudoephedrine3.0%580
15
Oxymorphone-hydrochloride2.8%543

Taken alongside

1
Acetaminophen22.9%4,374
2
Dexamethasone13.1%2,496
3
Pseudoephedrine10.6%2,024
4
Ondansetron9.9%1,891
5
Omeprazole9.5%1,813
6
Albuterol8.3%1,587
7
Aspirin8.2%1,573
8
Furosemide8.2%1,560
9
Hydrocortisone8.1%1,551
10
Phenylpropanolamine7.2%1,379
11
Hydrocodone7.1%1,351
12
Ranitidine7.1%1,348
13
Metoclopramide-hydrochloride6.9%1,316
14
Amoxicillin6.1%1,164
15
Levothyroxine-sodium6.0%1,153

Co-occurrence in adverse event reports does not establish a drug interaction. Patients often take multiple medications, and these lists reflect prescribing patterns rather than causal relationships. Consult a healthcare provider about potential drug interactions.

Who reports chlorpheniramine side effects

53.1% of chlorpheniramine adverse event reports involve female patients and 38.9% involve male patients. The largest age group is adult at 58%. These figures reflect who reports side effects, not underlying risk.

Sex

Female53.1%
Male38.9%
Unknown8.0%

Age group

< 21.2%
2–114.2%
12–173.0%
18–6457.6%
65+34.0%

What is chlorpheniramine used for

Conditions and purposes for which patients were taking chlorpheniramine when the adverse event was reported.

Abdominal DiscomfortAbdominal PainAccidental ExposureAccidental Exposure To ProductAccidental OverdoseAcute Graft Versus Host DiseaseAcute Lymphocytic LeukaemiaAdjuvant TherapyAdministration Related ReactionAdverse Drug ReactionAdverse EventAdverse ReactionAgeusiaAgitationAllergic Cough

Showing 15 of 607 indications

Chlorpheniramine brand names and reporting trend

Chlorpheniramine is sold under brand names including Corsym, Kloromin.

Brand names

Corsym27
Kloromin1

Quarterly reports (20042025)

20052010201520202025

An upward trend reflects increased FAERS reporting overall, not necessarily increased risk.

Taking chlorpheniramine with another medication?

Ask OpenClaim about your specific drug combination. Get a sourced report using FDA data, drug labels, and medical literature.